BMC Cancer Tutorials

1. Overexpression of extracellular superoxide dismutase reduces acute radiation induced lung toxicity

By Background: Acute RT-induced damage to the lung is characterized by inflammatory changes, which proceed to the development of fibrotic lesions in the late phase of injury. Ultimately, complete structural ablation will ensue, if the source of inflammatory / fibrogenic mediators and oxidative stress is not removed or attenuated. Therefore, the purpose of this study is to determine whether overexpres... read more

2. Myeloid antigens in childhood lymphoblastic leukemia:clinical data point to regulation of CD66c distinct from other myeloid antigens

By Myeloid antigens in childhood lymphoblastic leukemia:clinical data point to regulation of CD66c distinct from other myeloid antigens Tomas Kalina , Martina Vaskova , Ester Mejstrikova , Jozef Madzo , Jan Trka , Jan Stary and Ondrej Hrusak BMC Cancer 2005, 5:38     doi:10.1186/1471-2407-5-38 Published   12 April&... read more

3. Colon cancer in Luxembourg: a national population-based data report, 1988-1998

By Background: Over the last two decades time trends in incidence rates of colorectal cancer, changes in the proportions of stage at diagnosis and changes in the anatomic sub-site distribution of colon cancers have been reported in some European countries. In order to determine a strategy for early detection of colon cancer in the Grand-Duchy of Luxembourg, all consecutive colon adenocarcinomas diag... read more

4. Regular aspirin use and lung cancer risk

By Regular aspirin use and lung cancer risk Kirsten B Moysich1 , Ravi J Menezes1 , Adrienne Ronsani2 , Helen Swede3 , Mary E Reid1 , K Michael Cummings1 , Karen L Falkner1 , Gregory M Loewen1 and Gerold Bepler4 1Roswell Park Cancer Institute, Buffalo, NY, USA 2... read more

5. Tamoxifen stimulates arachidonic acid release from rat liver cells by an estrogen receptor-independent, non-genomic mechanism

By Tamoxifen stimulates arachidonic acid release from rat liver cells by an estrogen receptor-independent, non-genomic mechanism Lawrence Levine Department of Biochemistry, Brandeis University, Waltham, MA 02454, U.S.A BMC Cancer 2003, 3:24     doi:10.1186/1471-2407-3-24 The electronic version of this article is the complete ... read more

6. Differences in gene expression in prostate cancer, normal appearing prostate tissue adjacent to cancer and prostate tissue from cancer free organ dono

By Background: Typical high throughput microarrays experiments compare gene expression across two specimen classes - an experimental class and baseline (or comparison) class. The choice of specimen classes is a major factor in the differential gene expression patterns revealed by these experiments. In most studies of prostate cancer, histologically malignant tissue is chosen as the experimental clas... read more

7. Intraoperative radiation therapy (IORT) for previously untreated malignant gliomas

By Intraoperative radiation therapy (IORT) for previously untreated malignant gliomas Kenji Nemoto1 , Yoshihiro Ogawa1 , Haruo Matsushita1 , Ken Takeda1 , Yoshihiro Takai1 , Shogo Yamada1 and Toshihiro Kumabe2 1Department of Radiation Oncology, Tohoku University School of Medicine, Sendai, ... read more

8. Maspin overexpression modulates tumor cell apoptosis through the regulation of Bcl-2 family proteins

By Background: Maspin is a member of serpin family with tumor suppressing activity. Recent studies of maspin in animal models strongly support maspin's role as an inhibitor against the growth of primary tumor sand the process of metastasis. However, the molecular mechanism underlying this inhibition has not been fully elucidated. In this report, we analyze the effect of maspin on tumor cell apoptosi... read more

9. Potential role and chronology of abnormal expression of the Deleted in Colon Cancer (DCC) and the p53 proteins in the development of gastric cancer

By Potential role and chronology of abnormal expression of the Deleted in Colon Cancer (DCC) and the p53 proteins in the development of gastric cancer Francesco Graziano1 , Stefano Cascinu2 , Maria Pia Staccioli3 , Vincenzo Catalano4 , Maria Cristina Rossi4 , Anna Maria Baldelli4 , Paolo Giordani4 , Pietro Murett... read more

10. Surface TRAIL decoy receptor-4 expression is correlated with TRAIL resistance in MCF7 breast cancer cells

By Background: Tumor Necrosis Factor (TNF)-Related Apoptosis-Inducing Ligand (TRAIL) selectively induces apoptosis in cancer cells but not in normal cells. Despite this promising feature, TRAIL resistance observed in cancer cells seriously challenged the use of TRAIL as a death ligand in gene therapy. The current dispute concerns whether or not TRAIL receptor expression pattern is the primary determ... read more

11. Quantitative evaluation and modeling of two-dimensional neovascular network complexity: the surface fractal dimension

By Quantitative evaluation and modeling of two-dimensional neovascular network complexity: the surface fractal dimension Fabio Grizzi1, 2 , Carlo Russo1, 2 , Piergiuseppe Colombo3 , Barbara Franceschini1, 2 , Eldo E Frezza4 , Everardo Cobos5 and Maurizio Chiriva-Internati6 read more

12. Increased expression of AP2 and Sp1 transcription factors in human thyroid tumors: a role in NIS expression regulation?

By Increased expression of AP2 and Sp1 transcription factors in human thyroid tumors: a role in NIS expression regulation? Eusebio Chiefari1 , Antonio Brunetti1 , Franco Arturi1 , Jean-Michel Bidart2 , Diego Russo3 , Martin Schlumberger2 and Sebastiano Filetti4 1Department of Experimental a... read more

13. Evaluation of safety and efficacy of gefitinib ('iressa', zd1839) as monotherapy in a series of Chinese patients with advanced non-small-cell lung can

By Evaluation of safety and efficacy of gefitinib ('iressa', zd1839) as monotherapy in a series of Chinese patients with advanced non-small-cell lung cancer: experience from a compassionate-use programme Xin-Lin Mu , Long-Yun Li , Xiao-Tong Zhang , Shu-Lan Wang and Meng-Zhao Wang Department of Respiratory Diseases, Peking Union Medical College Hospital, Peking Union Medical Co... read more

14. Expression of nm23-H1 gene product in esophageal squamous cell carcinoma and its association with vessel invasion and survival

By Expression of nm23-H1 gene product in esophageal squamous cell carcinoma and its association with vessel invasion and survival Masaki Tomita , Takanori Ayabe , Yasunori Matsuzaki , Masao Edagawa , Masayuki Maeda , Tetsuya Shimizu , Masaki Hara and Toshio Onitsuka Department of Surgery II, Miyazaki Medical College Kihara 5200, Kiyotake, Miyazaki, 889-1692, Japan BMC C... read more

15. Preponderance of the oncogenic V599E and V599K mutations in B-raf kinase domain is enhanced in melanoma cutaneous/subcutaneous metastases

By Background: Downstream of Ras, the serine/threonine kinase B-raf has been reported to be mutated, among other carcinomas, in a substantial subset of primary melanomas with a preponderance of mutations within the kinase domain including the activating V599E and V599K transitions. Methods: We here investigated a representative series of 60 resection specimens of cutaneous and subcutaneous melano... read more

16. Correction: Global and regional estimates of cancer mortality and incidence by site: II. results for the global burden of disease 2000

By Correction: Global and regional estimates of cancer mortality and incidence by site: II. results for the global burden of disease 2000 Kenji Shibuya1 , Colin D Mathers1 , Cynthia Boschi-Pinto2 , Alan D Lopez3 and Christopher JL Murray4 1Global Program on Evidence for Health Policy, World Health Organization, ... read more

17. A novel duplication polymorphism in the FANCApromoter and its association with breast and ovarian cancer

By A novel duplication polymorphism in the FANCApromoter and its association with breast and ovarian cancer Ella Thompson , Rebecca L Gully , Sally-Anne Stephenson , Diana M Eccles , Ian G Campbell and Alexander Dobrovic BMC Cancer 2005, 5:43     doi:10.1186/1471-2407-5-43 Published   29 April 2005 ... read more

18. Prevalence of von Hippel-Lindau gene mutations in sporadic renal cell carcinoma: results from the Netherlands cohort study

By Background: Biallelic Von Hippel-Lindau (VHL) gene defects, a rate-limiting event in the carcinogenesis, occur in approximately 75% of sporadic clear-cell Renal Cell Carcinoma (RCC). We studied the VHL mutation status in a large population-based case group. Methods: Cases were identified within the Netherlands cohort study on diet and cancer, which includes 120,852 men and women. After 11.3 yea... read more

19. Patient satisfaction in the outpatients' chemotherapy unit of Marmara University, Istanbul, Turkey: a staff survey

By Patient satisfaction in the outpatients' chemotherapy unit of Marmara University, Istanbul, Turkey: a staff survey Nazim S Turhal , Basak Efe , Mahmut Gumus , Mehmet Aliustaoglu , Ayla Karamanoglu and Meric Sengoz Marmara University, Department of Internal Medicine, Division of Oncology, Istanbul, Turkey BMC Cancer 2002, 2:30     doi:10.... read more

20. Do hormonal contraceptives stimulate growth of neurofibromas? A survey on 59 NF1 patients

By Do hormonal contraceptives stimulate growth of neurofibromas? A survey on 59 NF1 patients Marge Lammert , Victor-Felix Mautner and Lan Kluwe Department of Maxillofacial Surgery, University Hospital Eppendorf, Hamburg, Germany BMC Cancer 2005, 5:16     doi:10.1186/1471-2407-5-16 The electronic version of this article is th... read more

21. Rectal cancer in Luxembourg : a national population-based data report, 1988–1998

By Rectal cancer in Luxembourg : a national population-based data report, 1988–1998 René Scheiden1, 2 , Julien Sand2 , Joseph Weber3 , Philippe Turk4 , Yolande Wagener5 and Catherine Capesius2 1division of pathology, National Health Laboratory, Luxembourg 2Morpholog... read more