Retrovirology Tutorials A searchable, browsable, archive of articles about everything under the sun. Retrovirology Quantification of HTLV-I proviral load in experimentally infected rabbits,,Dual effect of the SR proteins ASF/SF2, SC35 and 9G8 on HIV-1 RNA splicing and virion production

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1. Quantification of HTLV-I proviral load in experimentally infected rabbits

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Background Levels of proviral load in HTLV-1 infected patients correlate with clinical outcome and are reasonably prognostic. Adaptation of proviral load measurement techniques is examined here for use in an experimental rabbit model of HTLV-1 infection. Initial efforts sought to correlate proviral load with route and dose of inoculation and with clinical outcome in this model. These methods con... read more

2. Dual effect of the SR proteins ASF/SF2, SC35 and 9G8 on HIV-1 RNA splicing and virion production

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In HIV-1 infected cells transcription of the integrated provirus generates the single full length 9 kb viral RNA a major fraction of which is spliced to produce the single-spliced 4 kb RNAs and the multiple-spliced 2 kb RNAs. These spliced RNAs are the messengers for the Env glycoproteins and the viral regulatory factors. The cellular SR and hnRNP proteins were shown in vitro to control alternat... read more

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