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Ventricular metastasis resulting in disseminated intravascular coagulation

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Ventricular metastasis resulting in disseminated intravascular coagulation

Background: Disseminated Intravascular Coagulation (DIC) complicates up to 7% of malignancies, the commonest solid organ association being adenocarcinoma.

Category: World-Journal-of-Surgical-Oncology

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Background: Disseminated Intravascular Coagulation (DIC) complicates up to 7% of malignancies, the commonest solid organ association being adenocarcinoma. Transitional Cell Carcinoma (TCC) has rarely been associated with DIC.Case presentationA 74-year-old woman with TCC bladder and DIC was found to have a cardiac lesion suspicious for metastatic disease. The DIC improved with infusion of plasma and administration of Vitamin K, however the cardiac lesion was deemed inoperable and chemotherapy inappropriate given the patients functional status. We postulate that direct activation of the coagulation cascade by the intraventricular metastasis probably triggered the coagulopathy in this patient. Conclusions: Cardiac metastases should be considered in cancer patients with otherwise unexplained DIC. This may influence treatment choices. http://www.wjso.com/content/3/1/29

Thomas John and Ian D Davis

World Journal of Surgical Oncology 2005, 3:29

2005-05-24

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