Antimicrobial filtration article Number:7,520,923 from the United States Patent and Trademark Office (PTO) owispatent The present invention relates generally to a filtration article, such as a protective facemask, a method for using a filtration article, and a method for preparing a filtration article. In particular, the invention relates to a protective facemask that cost-effectively offers a broad spectrum of antimicrobial protection through the use of fibers treated with one or more oligodynamic metal and/or salt of an oligodynamic metal.<H Antimicrobial, filtration, Antimicrobial, f, 7520923.html, Patent, pto, 7520923

Title: Antimicrobial filtration article

Abstract: The present invention relates generally to a filtration article, such as a protective facemask, a method for using a filtration article, and a method for preparing a filtration article. In particular, the invention relates to a protective facemask that cost-effectively offers a broad spectrum of antimicrobial protection through the use of fibers treated with one or more oligodynamic metal and/or salt of an oligodynamic metal.

Patent Number: 7,520,923 Issued on 04/21/2009 to Marcoon

Inventors: Marcoon; Ken (Charleston, SC)
Assignee: MVP Textiles & Apparel, Inc. (Charleston, SC)

Appl. No.: 11/690,037

Filed: March 22, 2007

Current U.S. Class: 96/226 ; 128/205.26; 128/206.13; 128/206.19; 55/486; 55/524

Current International Class: B01D 46/00 (20060101)

Field of Search: 55/486,524 95/287 96/226,227,285 128/200.24,206.21,206.28,207.11,207.13,205.29,206.13,206.19

References Cited [Referenced By]

U.S. Patent Documents


1319763	October 1919	Drew
2813059	November 1957	Davis et al.
3710948	January 1973	Sexton
3761590	September 1973	Fox
3779244	December 1973	Weeks
3802429	April 1974	Bird
4042737	August 1977	Forsgren et al.
4197100	April 1980	Hausheer
4600002	July 1986	Maryyanek et al.
4677143	June 1987	Laurin
4798676	January 1989	Matkovich
4856509	August 1989	Lemelson
4883052	November 1989	Weiss et al.
4902503	February 1990	Umemura
5468738	November 1995	Okabayashi
5486410	January 1996	Groeger et al.
5525136	June 1996	Rosen
5607683	March 1997	Capelli
5706804	January 1998	Baumann et al.
5709870	January 1998	Yoshimura et al.
5747053	May 1998	Nashimoto
5792793	August 1998	Oda
5804295	September 1998	Braun et al.
5817325	October 1998	Sawan
5849311	December 1998	Sawan
5883026	March 1999	Reader et al.
5888527	March 1999	Nashimoto et al.
5906677	May 1999	Dudley
6036738	March 2000	Shanbrom
6045820	April 2000	Messier
6063170	May 2000	Deibert
6183932	February 2001	Asami
6303282	October 2001	Naruse
6337170	January 2002	Naruse
6514306	February 2003	Rohrbach et al.
6583176	June 2003	Arata
6623715	September 2003	Hendricks et al.
6681765	January 2004	Wen
6797278	September 2004	Jackson
6827764	December 2004	Springett et al.
6838095	January 2005	Newman
6872241	March 2005	Soane et al.
6897349	May 2005	Gibbins et al.
6905711	June 2005	Tullo et al.
6923990	August 2005	Capelli
6951833	October 2005	O'Neil
6989157	January 2006	Gillis
7044993	May 2006	Bolduc
7287650	October 2007	Koslow
2002/0025344	February 2002	Newman
2002/0123523	September 2002	Arata
2003/0176827	September 2003	Chandra et al.
2003/0186955	October 2003	Vange
2003/0191204	October 2003	Hermann et al.
2003/0198689	October 2003	Arata
2003/0205137	November 2003	Bolduc
2003/0207954	November 2003	Hermann et al.
2003/0216483	November 2003	Hermann et al.
2004/0009964	January 2004	Capelli
2004/0016345	January 2004	Springett et al.
2004/0110738	June 2004	Gillis
2004/0214809	October 2004	Capell
2004/0217049	November 2004	Bayer
2005/0048124	March 2005	Sarangapani
2005/0061678	March 2005	Holladay
2006/0045899	March 2006	Sarangapani
2006/0135941	June 2006	Porto
2006/0141015	June 2006	Tessier
2006/0154540	July 2006	Hilfenhaus
2006/0234899	October 2006	Nekmard et al.
2006/0254427	November 2006	Trend et al.
2007/0044801	March 2007	Mathis et al.

Foreign Patent Documents


8071029	Mar., 1996	JP
2000/154340	Jun., 2000	JP
WO 03/090799	Nov., 2003	WO
WO 2004/056403	Jul., 2004	WO
WO 2004/056404	Jul., 2004	WO

Other References

Francolini, I. et al., Feb. 2006, Novel metal-polyurethane complexes with enhanced antimicrobial activity, Macromolecular Rapid Communications, vol. 27, No. 4, pp. 233-237. cited by other .
Morrison, M.L. et al., Jan. 2006, Electrochemical and antimicrobial properties of diamondlike carbon-metal composite films, Diamond and Related Materials, vol. 15, No. 1, pp. 138-146. cited by other .
Tessier, D. et al., 2005, Antimicrobial fabrics coated with nano-sized silver salt crystals, NSTI Nanotech 2005, pp. 762-764 Nano Science and Technology Institute, Cambridge, MA (publisher). NSTI Nanotechnology Conference and Trade Show, May 8-12, 2005, Anaheim, CA. cited by other .
Song, J. S. et al., May 2005, Surface modification of silicone rubber by ion beam assisted deposition (IBAD) for improved biocompatibility, Journal of Applied Polymer Science, vol. 96, No. 4, pp. 1095-1101. cited by other .
Furno F. et al., Silver nanoparticles and polymeric medical devices: a new approach to prevention of infection? Journal of Antimicrobial Chemotherapy, vol. 54, No. 6, pp. 1019-1024. cited by other .
PCT International Search Report (PCT/US08/03761), mail date Nov. 19, 2008. cited by other.

Primary Examiner: Smith; Duane
Assistant Examiner: Turner; Sonji
Attorney, Agent or Firm: Hunton & Williams LLP

Claims

What is claimed is:

1. A filtration article comprising: an air permeable filtration layer comprising fibers treated with one or more oligodynamic metal and/or salt of an oligodynamic metal; an air permeable support layer operatively associated with said filtration layer, said support layer being configured to fit over the nose and mouth of a wearer; and an attachment element to secure said filtration article to the wearer.

2. The filtration article of claim 1, wherein said one or more oligodynamic metal is silver, mercury, copper, iron, lead, zinc, bismuth, gold, aluminum, platinum, palladium, iridium, tin, antimony, or any combination thereof.

3. The filtration article of claim 2, wherein said oligodynamic metal is silver.

4. The filtration article of claim 1, wherein said fibers comprise polyester, polyolefin, polyamide, polypropylene, acrylic, cotton, cellulose, or any combination thereof.

5. The filtration article of claim 1, wherein said fibers are about 0.3 mm to about 0.7 mm in diameter.

6. The filtration article of claim 1, wherein said fibers are about 0.4 mm to about 0.6 mm in diameter.

7. The filtration article of claim 1, wherein said fibers are about 0.5 mm in diameter.

8. The filtration article of claim 1, wherein said filtration layer comprises a hydrophilic foam into which the fibers treated with one or more oligodynamic metal and/or salt of an oligodynamic metal are disbursed.

9. The filtration article of claim 1, further comprising at least one secondary antimicrobial substance.

10. The filtration article of claim 9, wherein the secondary antimicrobial substance is an antibacterial agent, an antiviral agent, an antimold agent, an antiyeast agent, an antifungal agent, or any combination thereof.

11. The filtration article of claim 1, wherein the filtration article is a facemask.

12. The filtration article of claim 11, wherein said facemask has a cone shape, duckbill shape, or flatfold shape.

13. A filtration article comprising: an air permeable filtration layer comprising fibers treated with one or more oligodynamic metal and/or salt of an oligodynamic metal, wherein said filtration layer comprises a sufficient concentration of said one or more oligodynamic metal and/or salt of an oligodynamic metal to capture and kill microbes in a volume of air moving through said filtration layer; an air permeable support layer operatively associated with said filtration layer, said support layer being configured to fit over the nose and mouth of a wearer; and an attachment element to secure said filtration article to the wearer.

14. The filtration article of claim 13, wherein said filtration layer comprises a sufficient concentration of said one or more oligodynamic metal and/or salt of an oligodynamic metal to capture and kill greater than 95% of microbes in a volume of air moving through said filtration layer.

15. The filtration article of claim 13, wherein said filtration layer comprises a sufficient concentration of said one or more oligodynamic metal and/or salt of an oligodynamic metal to capture and kill greater than 96% of microbes in a volume of air moving through said filtration layer.

16. The filtration article of claim 13, wherein said filtration layer comprises a sufficient concentration of said one or more oligodynamic metal and/or salt of an oligodynamic metal to capture and kill greater than 97% of microbes in a volume of air moving through said filtration layer.

17. The filtration article of claim 13, wherein said filtration layer comprises a sufficient concentration of said one or more oligodynamic metal and/or salt of an oligodynamic metal to capture and kill greater than 98% of microbes in a volume of air moving through said filtration layer.

18. The filtration article of claim 13, wherein said filtration layer comprises a sufficient concentration of said one or more oligodynamic metal and/or salt of an oligodynamic metal to capture and kill greater than 99% of microbes in a volume of air moving through said filtration layer.

19. The filtration article of claim 13, wherein said one or more oligodynamic metal is silver, mercury, copper, iron, lead, zinc, bismuth, gold, aluminum, platinum, palladium, iridium, tin, antimony, or any combination thereof.

20. The filtration article of claim 19, wherein said oligodynamic metal is silver.

21. The filtration article of claim 13, wherein said fibers comprise polyester, polyolefin, polyamide, polypropylene, acrylic, cotton, cellulose, or any combination thereof.

22. The filtration article of claim 13, wherein said fibers are about 0.3 mm to about 0.7 mm in diameter.

23. The filtration article of claim 13, wherein said fibers are about 0.4 mm to about 0.6 mm in diameter.

24. The filtration article of claim 13, wherein said fibers are about 0.5 mm in diameter.

25. The filtration article of claim 13, wherein said filtration layer comprises a hydrophilic foam into which fibers treated with one or more oligodynamic metal and/or salt of an oligodynamic metal are disbursed.

26. The filtration article of claim 13, further comprising at least one secondary antimicrobial substance.

27. The filtration article of claim 26, wherein the secondary antimicrobial substance is an antibacterial agent, an antiviral agent, an antimold agent, an antiyeast agent, an antifungal agent, or any combination thereof.

28. The filtration article of claim 13, wherein the filtration article is a facemask.

29. The filtration article of claim 28, wherein said facemask has a cone shape, duckbill shape, or flatfold shape.

30. A filtration article comprising: an air permeable filtration layer comprising fibers treated with one or more oligodynamic metal and/or salt of an oligodynamic metal, wherein the concentration of said one or more oligodynamic metal and/or salt of an oligodynamic metal in the filtration layer is between about 10 parts per million to about 10,000 parts per million; an air permeable support layer operatively associated with said filtration layer, said support layer being configured to fit over the nose and mouth of a wearer; and an attachment element to secure said filtration article to the wearer.

31. The filtration article of claim 30, wherein the concentration of said one or more oligodynamic metal and/or salt of an oligodynamic metal in the filtration layer is between about 50 parts per million to about 5,000 parts per million.

32. The filtration article of claim 30, wherein the concentration of said one or more oligodynamic metal and/or salt of an oligodynamic metal in the filtration layer is between about 100 parts per million to about 2,000 parts per million.

33. The filtration article of claim 30, wherein said one or more oligodynamic metal is silver, mercury, copper, iron, lead, zinc, bismuth, gold, aluminum, platinum, palladium, iridium, tin, antimony, or any combination thereof.

34. The filtration article of claim 33, wherein said oligodynamic metal is silver.

35. The filtration article of claim 30, wherein said fibers comprise polyester, polyolefin, polyamide, polypropylene, acrylic, cotton, cellulose, or any combination thereof.

36. The filtration article of claim 30, wherein said fibers are about 0.3 mm to about 0.7 mm in diameter.

37. The filtration article of claim 30, wherein said fibers are about 0.4 mm to about 0.6 mm in diameter.

38. The filtration article of claim 30, wherein said fibers are about 0.5 mm in diameter.

39. The filtration article of claim 30, wherein said filtration layer comprises a hydrophilic foam into which the oligodynamic metal treated fibers are disbursed.

40. The filtration article of claim 30, further comprising at least one secondary antimicrobial substance.

41. The filtration article of claim 40, wherein the secondary antimicrobial substance is an antibacterial agent, an antiviral agent, an anti-mold agent, an anti-yeast agent, an antifungal agent, or any combination thereof.

42. The filtration article of claim 30, wherein the filtration article is a facemask.

43. The filtration article of claim 42, wherein said facemask has a cone shape, duckbill shape, or flatfold shape.

44. A filtration article prepared by the process comprising: treating fibers with one or more oligodynamic metal and/or salt of an oligodynamic metal, incorporating said fibers into an air permeable filtration layer, said filtration layer being operatively associated with an air permeable support layer configured to fit over the nose and mouth of a wearer.

45. The filtration article of claim 44, wherein said one or more oligodynamic metal is silver, mercury, copper, iron, lead, zinc, bismuth, gold, aluminum, platinum, palladium, iridium, tin, antimony, or any combination thereof.

46. The filtration article of claim 45, wherein said oligodynamic metal is silver.

47. The filtration article of claim 44, wherein said fibers comprise polyester, polyolefin, polyamide, polypropylene, acrylic, cotton, cellulose, or any combination thereof.

48. The filtration article of claim 44, wherein said fibers are about 0.3 mm to about 0.7 mm in diameter.

49. The filtration article of claim 44, wherein said fibers are about 0.4 mm to about 0.6 mm in diameter.

50. The filtration article of claim 44, wherein said fibers are about 0.5 mm in diameter.

51. The filtration article of claim 44, wherein said filtration layer comprises a hydrophilic foam into which the oligodynamic metal treated fibers are disbursed.

52. The filtration article of claim 44, further comprising at least one secondary antimicrobial substance.

53. The filtration article of claim 52, wherein the secondary antimicrobial substance is an antibacterial agent, an antiviral agent, an antimold agent, an antiyeast agent, an antifungal agent, or any combination thereof.

54. The filtration article of claim 44, wherein the filtration article is a facemask.

55. The filtration article of claim 54, wherein said facemask has a cone shape, duckbill shape, or flatfold shape.

56. A filtration article comprising: an air permeable filtration layer comprising fibers treated with an oligodynamic metal and/or salt of an oligodynamic metal comprising silver or silver chloride and hydrophilic foam, wherein the concentration of said fibers in said filtration layer is between about 100 parts per million to about 2,000 parts per million and said fibers are about 0.5 mm in diameter; an air permeable support layer operatively associated with said filtration layer, said support layer being configured to fit over the nose and mouth of a wearer; and an attachment element to secure said filtration article to the wearer.

57. A filtration article prepared by the process comprising: treating fibers with an oligodynamic metal and/or salt of an oligodynamic metal comprising silver or silver chloride; incorporating said fibers into an air permeable filtration layer comprising hydrophilic foam, wherein the concentration of said fibers in said filtration layer is between about 100 parts per million to about 2,000 parts per million and said fibers are about 0.5 mm in diameter; and operatively associating said filtration layer with an air permeable support layer and an attachment element, said support layer being configured to fit over the nose and mouth of a wearer and said attachment element configured to secure said filtration article to the wearer.

Description

FIELD OF THE INVENTION

The present invention relates generally to a filtration article, such as a facemask, the use of a filtration article, and a method for preparing a filtration article. In particular, the invention relates to a filtration article that offers antimicrobial protection through the use of fibers treated with one or more oligodynamic metal and/or salt of an oligodynamic metal.

BACKGROUND OF THE INVENTION

Due to the risk of infection by pathogens, such as airborne pathogens, the use of protective facemasks has become part of standard practice in many settings, such as in hospitals and other medical facilities, by those who come into contact with patients. Protective facemasks are also widely used by others, such as medical professionals and other healthcare workers, for example, paramedics and emergency medical technicians, who interact with patients outside formal treatment settings. Typically, a facemask is worn by the medical professional or other healthcare worker to protect both the wearer and patient from transmission of any infective agent. For example, the facemask can be used to protect a healthcare worker from an infected patient. Likewise, the facemask can be used to protect a vulnerable patient from exposure to pathogens, for example a patient undergoing a surgical procedure or an immunocompromised patient. As such, protective facemasks are an essential component of a healthcare worker's personal protective equipment. Of course, it may also be beneficial for certain patients or individuals who are immunocompromised or particularly susceptible or vulnerable to infection to also wear such protective facemasks. Protective facemasks may also be useful for distribution to the general public in cases of epidemics or pandemics, as well as in cases of any widespread release of pathogens or agents containing pathogens, whether intentional or unintentional. An effective facemask represents a critical barrier in preventing the transmission of harmful infections.

Various designs and configurations for facemasks have been previously proposed. One class of masks uses a filter network to trap the pathogens. These facemasks include the surgical type masks commonly worn in hospitals. One example is described in U.S. Pat. No. 7,044,993 to Bolduc entitled "Microbicidal air filter." Bolduc discloses a system that employs an immobilization network of fibers having antimicrobial agents incorporated and molecularly bonded into its structure. Another class of masks include those that employ filter canisters to trap the pathogens. One example is described in U.S. Pat. No. 6,681,765 to Wen entitled "Antiviral and antibacterial respirator mask." Wen discloses a system that employs a filtration apparatus containing both an active stage and passive stage filter in the mask.

The aforesaid designs and other previously proposed facemasks suffer from a number of important shortcomings. For example, some designs may only immobilize and not neutralize the airborne pathogens. Thus, removal of a facemask after use may cause pathogens not completely immobilized to be dispersed into the air immediately around the user. The pathogen may cause an infection if inhaled or may pose a contact transmission risk via the hands during the disposal process. In addition, some of the designs incorporate viscous material into the filter material to capture particulate material, while other designs incorporate complex arrangements of filters inside cartridges. These designs may be impractical for use in facemasks. For example, they may be too complex and cumbersome to routinely use as well as too expensive. In other cases, material harmful to humans, such as fiberglass, iodine, or chlorine, are used as part of the filter medium. Another facemask design uses antibacterial agents that freely detach from fibers of the facemask. These designs have the problem of a rapid loss of their antibacterial activity upon cleaning or washing thereof.

As is apparent from the foregoing, all of the previously proposed techniques to retain and neutralize microbes are characterized to some degree by deficiencies. Accordingly, there is a considerable need for an improved antimicrobial facemask. In particular, there is a need for an antimicrobial facemask that is both effective, safe, comfortable, durable, easy to use and store and relatively inexpensive to produce.

SUMMARY OF THE INVENTION

An embodiment of the present invention provides a filtration article comprising: an air permeable filtration layer comprising fibers treated with one or more oligodynamic metal and/or salt of an oligodynamic metal; an air permeable support layer operatively associated with said filtration layer, said support layer being configured to fit over the nose and mouth of a wearer; and an attachment element to secure said filtration article to the wearer.

A further embodiment of the present invention provides a filtration article comprising: an air permeable filtration layer comprising fibers treated with one or more oligodynamic metal and/or salt of an oligodynamic metal, said filtration layer comprises a sufficient concentration of said one or more oligodynamic metal and/or salt of an oligodynamic metal to capture and kill microbes in a volume of air moving through said filtration layer; an air permeable support layer operatively attached to said filtration layer, said support layer being configured to fit over the nose and mouth of a wearer; and an attachment element to secure said filtration article to the wearer.

An even further embodiment of the present invention provides a filtration article comprising: an air permeable filtration layer comprising fibers treated with one or more oligodynamic metal and/or salt of an oligodynamic metal, wherein the concentration of said one or more oligodynamic metal and/or salt of an oligodynamic metal in the filtration layer is between about 10 parts per million to about 10,000 parts per million; an air permeable support layer operatively attached to said filtration layer, said support layer being configured to fit over the nose and mouth of a wearer; and an attachment element to secure said filtration article to the wearer.

A still further embodiment of the present invention provides a method of preparing a filtration article comprising: treating fibers with one or more oligodynamic metal and/or salt of an oligodynamic metal; incorporating said fibers into an air permeable filtration layer, said filtration layer being operatively associated with an air permeable support layer configured to fit over the nose and mouth of a wearer.

Another embodiment of the present invention provides a filtration article prepared by the process comprising: treating fibers with one or more oligodynamic metal and/or salt of an oligodynamic metal; and incorporating said fibers into an air permeable filtration layer, said filtration layer operatively associated to an air permeable support layer configured to fit over the nose and mouth of an wearer.

A further embodiment of the present invention provides a filtration article comprising: an air permeable filtration layer comprising fibers treated with silver or silver chloride and hydrophilic foam, wherein the concentration of said fibers in said filtration layer is between about 100 parts per million to about 2,000 parts per million and said fibers are about 0.5 mm in diameter; an air permeable support layer operatively associated with said filtration layer, said support layer being configured to fit over the nose and mouth of a wearer; and an attachment element to secure said filtration article to the wearer.

An even further embodiment of the present invention provides a method of preparing a filtration article comprising: treating fibers with silver or silver chloride; incorporating said fibers into an air permeable filtration layer comprising hydrophilic foam, wherein the concentration of said fibers in said filtration layer is between about 100 parts per million to about 2,000 parts per million and said fibers are about 0.5 mm in diameter; and operatively associating said filtration layer with an air permeable support layer and an attachment element, said support layer configured to fit over the nose and mouth of a wearer and said attachment element configured to secure said filtration article to the wearer.

A still further embodiment of the present invention provides a filtration article prepared by the process comprising: treating fibers with silver or silver chloride; incorporating said fibers into an air permeable filtration layer comprising hydrophilic foam, wherein the concentration of said fibers in said filtration layer is between about 100 parts per million to about 2,000 parts per million and said fibers are about 0.5 mm in diameter; and operatively associating said filtration layer with an air permeable support layer and an attachment element, said support layer configured to fit over the nose and mouth of a wearer and said attachment element configured to secure said filtration article to the wearer.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 provides an illustration of an antimicrobial flatfold facemask with a cutaway section showing the inner layers of the facemask according to an embodiment of the present invention.

FIG. 2 provides an illustration of a cross-sectional view of an embodiment of the present invention.

DETAILED DESCRIPTION OF THE INVENTION

For the purposes of promoting an understanding of the embodiments described herein, reference will be made to various embodiments and specific language will be used to describe the same. The terminology used herein is for the purpose of describing particular embodiments only, and is not intended to limit the scope of the present invention. As used throughout this disclosure, the singular forms "a", "an", and "the" include plural reference unless the context clearly dictates otherwise.

As used herein, the term "microbe" or "microbial" is intended to mean microorganisms including, but not limited to, bacteria, protozoa, viruses, molds, fungi, yeast and the like. The term "antimicrobial" is intended to mean the property of inhibiting, preventing, or destroying the growth or proliferation of microbes such as bacteria, protozoa, viruses, molds, fungi, yeast and the like. The term "neutralize" is intended to mean inhibiting, preventing, or destroying growth or proliferation.

The present invention provides a filtration article, such as facemask, that provides protection against transmission of microbial organisms, such as pathogens. The inventors unexpectedly discovered a filtration article that effectively retains and neutralizes a broad spectrum of pathogens. The filtration article incorporates a filtration layer that effectively retains and neutralizes a broad spectrum of pathogens by incorporating a relatively low concentration of one or more oligodynamic metal and/or salt of an oligodynamic metal into the layer. Although previously available facemasks are often unable to retain and/or neutralize greater than 95% of microbes, the filtration article in accordance with various embodiments of the present invention can retain and neutralize greater than 99% of microbes. Moreover, by using a low concentration of oligodynamic metal or oligodynamic metal salt, the cost of manufacturing the filtration article is relatively low. The present invention overcomes the deficiencies found in the previously available facemasks, including deficiencies such as overall effectiveness, relatively high cost of manufacture compared to effectiveness in retaining and neutralizing a broad spectrum of microbes, ease of use, comfort, durability and various other factors. For example, the filtration articles of the present invention do not impede flow of oxygen to the wearer or impede flow of carbon dioxide from the wearer. Further, the filtration articles of the present invention are comfortable to wear (even for long periods), easy to use, durable, compact and easily stored, readily disposable, safe and non-toxic.

Referring to FIG. 1, the details of one embodiment of the present invention is described in greater detail. The antimicrobial filtration article 100 is shown as a facemask similar to those generally worn by hospital workers designed to fit over the nose and mouth of a wearer. The antimicrobial filtration article has inner layers 200, an air permeable outer layer 210, and an attachment element 110. While the embodiment shown has a flatfold shape, the present invention is not limited to any particular style or configuration, and can include, but is not limited to, cone shape, duckbill shape, cup type, pocket type or interlining facemasks. Additionally, although the attachment elements 110 shown in this embodiment are straps for tying the facemask to the wearer, any suitable attachment element may be used. Examples of suitable attachment elements include, but are not limited to, hook and loop fasteners (such as VELCRO), straps, tabs, strings, elastic, buttons, ear loops, form fit, moldable attachment, adhesives, adhesive tabs, snaps or combinations thereof. The facemask according to the present invention may also incorporate other known facemask features including, but not limited to, visors, shields, beard covers, valves or combinations thereof.

Referring to FIG. 2, a cross-sectional view of the inner layers 200 in accordance with an embodiment of the present invention is provided. The inner layers 200 include an air permeable polymer foam layer 230 comprising fibers treated with one or more oligodynamic metal and/or salt of an oligodynamic metal 240, an air permeable layer 250, an inner filtration layer 260 comprising filter media 220, and an air permeable support layer 270. Also shown in FIG. 2 is the air permeable outer layer 210. The inventors found that by using fibers treated with one or more oligodynamic metal and/or salt of an oligodynamic metal in the filtration layer, the present invention was effective in retaining and neutralizing microbes. Additionally, the inventors found that the effectiveness of the filtration article to retain and neutralize microbes did not require a high concentration of the oligodynamic metal or oligodynamic metal salt in the filtration component. According to an embodiment, the total concentration of oligodynamic metal and/or oligodynamic metal salt in the filtration layer is between about 10 parts per million to about 10,000 parts per million. According to another embodiment, the total concentration of oligodynamic metal and/or oligodynamic metal salt in the filtration layer is between about 50 parts per million to about 5,000 parts per million. According to another embodiment, the total concentration of oligodynamic metal and/or oligodynamic metal salt in the filtration layer is between about 100 parts per million to about 2,000 parts per million. According to another embodiment, the total concentration of oligodynamic metal and/or oligodynamic metal salt used during the preparation of the filtration layer is between about 10 parts per million to about 10,000 parts per million. According to another embodiment, the total concentration of oligodynamic metal and/or oligodynamic metal salt used during the preparation of the filtration layer is between about 50 parts per million to about 5,000 parts per million. According to another embodiment, the total concentration of oligodynamic metal and/or oligodynamic metal salt used during the preparation of the filtration layer is between about 100 parts per million to about 2,000 parts per million.

The fibers in the filtration layer are treated with one or more oligodynamic metal, such as silver, and/or one or more salt of an oligodynamic metal, such as silver chloride, in accordance with various embodiments of the present invention. Any suitable process for treating a fiber with one or more oligodynamic metal and/or salt of an oligodynamic metal is contemplated by the present invention. Processes for treating fibers can include, but are not limited to, electroplating, electroless plating, vapor deposition, or combinations thereof. Suitable fibers treated with one or more oligodynamic metal and/or salt of one or more oligodynamic metal could be readily prepared by persons of skill in the art, based on the guidance provided herein.

According to another embodiment, silver treated fibers suitable for use with the filtration layer of the present invention include those manufactured as described in U.S. Pat. No. 4,042,737 and U.S. Pat. Application Publication No. 2003/0176827, which are hereby incorporated by reference.

The present invention contemplates the use of any suitable fibers. A person of skill in the art would readily recognize suitable fibers for use in the present invention, based upon the guidance provided herein. For example, fibers suitable for use with the filtration layer of the present invention can be made of materials including, but not limited to, cotton, cellulose, any polymeric material such as polyester, polyolefin, polyamide, polypropylene, acrylic, wool, regenerated cellulose or combinations thereof. According to an embodiment of the present invention, the fibers are about 0.3 mm to about 0.7 mm in diameter. According to another embodiment, the fibers are about 0.4 mm to about 0.6 mm in diameter. According to another embodiment, the fibers are about 0.5 mm in diameter.

Oligodynamic metals can include, but are not limited to, silver, mercury, copper, iron, lead, zinc, bismuth, gold, aluminum, platinum, palladium, iridium, tin, and antimony. Oligodynamic metal salts can include, but are not limited to, silver acetate, silver carbonate, silver chloride, silver citrate, silver cyanide, silver hydroxide, silver nitrate, silver nitrite, silver oxide, silver phosphate, silver sulfate, mercury acetate, mercury carbonate, mercury chloride, mercury citrate, mercury cyanide, mercury hydroxide, mercury nitrate, mercury nitrite, mercury oxide, mercury phosphate, mercury sulfate, copper acetate, copper carbonate, copper chloride, copper citrate, copper cyanide, copper hydroxide, copper nitrate, copper nitrite, copper oxide, copper phosphate, copper sulfate, iron acetate, iron carbonate, iron chloride, iron citrate, iron cyanide, iron hydroxide, iron nitrate, iron nitrite, iron oxide, iron phosphate, iron sulfate, lead acetate, lead carbonate, lead chloride, lead citrate, lead cyanide, lead hydroxide, lead nitrate, lead nitrite, lead oxide, lead phosphate, lead sulfate, zinc acetate, zinc carbonate, zinc chloride, zinc citrate, zinc cyanide, zinc hydroxide, zinc nitrate, zinc nitrite, zinc oxide, zinc phosphate, zinc sulfate, bismuth acetate, bismuth carbonate, bismuth chloride, bismuth citrate, bismuth cyanide, bismuth hydroxide, bismuth nitrate, bismuth nitrite, bismuth oxide, bismuth phosphate, bismuth sulfate, gold acetate, gold carbonate, gold chloride, gold citrate, gold cyanide, gold hydroxide, gold nitrate, gold nitrite, gold oxide, gold phosphate, gold sulfate, aluminum acetate, aluminum carbonate, aluminum chloride, aluminum citrate, aluminum cyanide, aluminum hydroxide, aluminum nitrate, aluminum nitrite, aluminum oxide, aluminum phosphate, aluminum sulfate, platinum acetate, platinum carbonate, platinum chloride, platinum citrate, platinum cyanide, platinum hydroxide, platinum nitrate, platinum nitrite, platinum oxide, platinum phosphate, platinum sulfate, palladium acetate, palladium carbonate, palladium chloride, palladium citrate, palladium cyanide, palladium hydroxide, palladium nitrate, palladium nitrite, palladium oxide, palladium phosphate, palladium sulfate, iridium acetate, iridium carbonate, iridium chloride, iridium citrate, iridium cyanide, iridium hydroxide, iridium nitrate, iridium nitrite, iridium oxide, iridium phosphate, iridium sulfate, tin acetate, tin carbonate, tin chloride, tin citrate, tin cyanide, tin hydroxide, tin nitrate, tin nitrite, tin oxide, tin phosphate, tin sulfate, antimony acetate, antimony carbonate, antimony chloride, antimony citrate, antimony cyanide, antimony hydroxide, antimony nitrate, antimony nitrite, antimony oxide, antimony phosphate, antimony sulfate, or combinations thereof. Suitable oligodynamic metals or oligodynamic metal salts could be readily obtained or prepared by persons of skill in the art based on the guidance provided herein.

The use of one or more oligodynamic metal and/or salt of an oligodynamic metal renders the filtration article of the present invention effective against a broad spectrum of microbes. Examples of microbes that the filtration article of the present invention are effective against include pathogens that can cause disease or illness in a human, such as various bacteria, viruses, protists, fungi, molds, yeasts, and the like, without limitation. The present invention contemplates pathogens that cause any type of infection, including nosocomial, opportunistic, hospital-acquired and/or post-surgical wound infections, without limitation. The present invention contemplates effectiveness against natural pathogens, recombinantly prepared pathogens or pathogens synthetically produced (e.g., manmade in a laboratory) by any means or any combination thereof, without limitation. The present invention also contemplates effectiveness against drug-resistant pathogens. The following is an exemplary list of specific pathogens that the present invention contemplates, without intending to be limited thereto, Parvovirus B19, Rhinovirus, Coxsackievirus, Echovirus, Hantavirus, Togavirus, Reovirus, Adenovirus, Orthomyxovirus-Influenza, Coronavirus, Morbillivirus, Varicella-zoster, Arenavirus-Junin, Arenavirus-Machupo, Arenavirus-Lassa, Filovirus-Marburg, Parainfluenza, Repiratory Syncytial Virus, Poxvirus-Variola, Poxvirus-Vaccinia, Monkeypox, Paramyxovirus, Francisella tularensis, Bordetella pertussis, Mycoplasma pneumoniae, Chlamydia pneumoniae, Chlamydia psittaci, Klebsiella pneumoniae, Haemophilus influenzae, Coxiella burnetii, Pseudomonas pseudomallei, Actinomyces israelii, Legionella parisiensis, Legionella pneumophila, Cardiobacterium, Alkaligenes, Yersinia pestis, Pseudomonas cepacia, Enterobacter cloacae, Enterococcus, Neisseria meningitidis, Streptococcus faecalis, Streptococcus pyogenes, Mycobacterium kansasii, Mycobacterium tuberculosis, Streptococcus pneumoniae, Staphylococcus aureus, Staphylococcus epidermis, Corynebacteria diphtheria, Clostridium tetani, Haemophilus parainfluenzae, Moraxella lacunata, Bacillus anthracis, Mycobacterium avium, Mycobacterium intracellulare, Acinetobacter, Moraxella catarrhalis, Serratia marcescens, Saccharomonospora viridis, Thermomonospora viridis, Micropolyspora faeni, Thermoactinomyces sacchari, Micromonosporafaeni, Thermoactinomyces vulgaris, Nocardia asteroides, Nocardia brasiliensis, Nocardia caviae, Phialaphora parasitica, Phialaphora repens, Exophiala jeanselmei, Phialaphora hoffmannii, Phialaphora richardsiae, Pneumocystis carinii, Phialaphora mutabilis, Acremonium spp., Trichoderma harzianum, Oidiodendron tenuissimum, Geomyces pannorum, Histoplasma capsulatum, Paecilomyces variotii, Wallemia sebi, Emericella nidulans, Phoma spp., Penicillium brevicompactum, Penicillium chrysogenum, Penicillium citreonigrum, Penicillium commune, Penicillium corylophilum, Penicillium cyclopium, Penicillium expansum, Penicilliumfreii, Penicillium glabrum, Penicillium hordei, Penicillium olsonii, Penicillium polonicum, Penicillium rugulosum, Penicillium solitum, Aspergillus flavus, Aspergillus fumigatus, Aspergillus niger, Aspergillus versicolor, Absidia corymbifera, Coccidioides immitis, Trichoderma viride, Rhizomucor pusillus, Aureobasidium pullulans, Candida albicans, Chaetomium globosum, Cryptococcus albidus, Cryptococcus laurentii, Cryptococcus neoformans, Stachybotris atra, Stachybotris chartarum, Eurotium amstelodami, Eurotium herbariorium, Eurotium rubrum, Scopulariopsis brevicaulis, Scopulariopsis fusca, Sporothrix schenckii, Botrytis cinera, Mucor plumbeus, Rhizopus stolonifer, Cladosporium cladosporioides, Cladosporium herbarum, Cladosporium sphaerospermum, Fusarium culmorum, Fusarium graminearum, Fusarium moniliforme, Fusarium solani, Fusarium sporotrichioides, Helminthosporium, Blastomyces dermatitidis, Rhodoturula glutinus, Rhodoturula minuta, Rhodoturula mucilaginosa, Alternaria alternata, Ulocladium botrytis, Ulocladium chartarum, Paracoccidioides brasiliensis, Epicoccum nigrum, or combinations thereof.

Referring back to FIG. 2, the filtration layer of the present embodiment includes the fibers treated with one or more oligodynamic metal and/or salt of an oligodynamic metal 201 disbursed in a polymer 202. According to an embodiment, the filtration article includes multiple layers. For example, without limitation, a filtration article in accordance with an embodiment of the present invention includes an outmost layer which is a cover layer, a hydrophilic foam layer (comprising fibers treated with a metal or salt of a metal), a filtration media and a guard layer. The cover layer, foam layer, filtration media and guard layer can be of any suitable substance or substances as would be recognized by a person of skill in the art based upon the guidance provided herein. For example, without limitation, each layer may comprise a polymer or the like. One or more additional layers containing one or more additional antimicrobial agent, including one or more additional fiber treated with a metal and/or salt of a metal are contemplated in accordance with various embodiments of the present invention. Polymers suitable for use in the air permeable filtration layer can be hydrophobic polymers, hydrophilic polymers, or combinations thereof. Such polymers include, but are not limited to, polyurethane, polypropylene, polyvinylchloride, polyolefin, polyester, polyethylene oxide, polyamide, or combinations thereof. According to one embodiment, the filtration layer of the present invention includes a polyurethane hydrophilic foam. Hydrophilic foams that are suitable for use with the present invention are described in U.S. Pat. Application Publication Nos. 2003/0191204, 2003/0207954, 2003/0216483, and 2006/0234899, which are incorporated herein by reference. Suitable polymers could be readily prepared by persons of skill in the art based on the guidance provided herein. In a process according to an embodiment of the present invention, an outermost cover layer is constructed of approximately 20 gsm polypropylene to which a hydrophilic layer in which silver fibers are embedded is added; the foam layer is rolled onto another 20 gsm polypropylene layer (on the opposite side of the foam layer as the outer layer); next, a filtration media composed of dense polypropylene is added; and the final and innermost layer is a guard layer composed of polyester, polypropylene or a combination thereof.

The present invention contemplates that the filtration layer can additionally include one or more secondary antimicrobial substance. Suitable secondary antimicrobial substances can include antibacterial agents, antiviral agents, antimold agents, antiyeast agents, antifungal agents, or any combinations thereof, without intending to be limited thereto. A suitable secondary antimicrobial substances could be readily obtained or prepared by persons of skill in the art based on the guidance provided herein.

The present invention also provides methods of preparing an antimicrobial filtration article in accordance with various embodiments. According to an embodiment of the present invention, fibers are treated with one or more oligodynamic metal and/or salt of an oligodynamic metal. The method of treating the fibers with one or more oligodynamic metal and/or salt of an oligodynamic metal can include, but is not limited to, electroplating, electroless plating, vapor deposition, or combinations thereof. The treated fibers are incorporated into the filtration layer of a filtration article in accordance with various embodiments of the present invention.

According to an embodiment of the present invention, a method of producing a fiber treated with an oligodynamic metal is described in U.S. Pat. No. 4,042,737 and U.S. Pat. Application Publication No. 2003/0176827, which are hereby incorporated by reference. In accordance with this embodiment, a wet processing technique is used for treating fibers with an oligodynamic metal salt. The technique involves passing a substrate of a knitted fabric into a bath of a salt of the metal to be deposited together with a reducing agent for the metal component of the salt. According to an embodiment a treated fiber is prepared by the plating of silver onto a knitted nylon fabric from an aqueous bath of silver nitrate and formaldehyde. An example of one comme