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Apparatus and method for dose administration in brachytherapy Number:7,041,048 from the United States Patent and Trademark Office (PTO) owispatent

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Title: Apparatus and method for dose administration in brachytherapy

Abstract: An apparatus and method for administering a dose in brachytherapy procedures having a handheld housing containing a dose of radioactive seeds adapted for use in a brachytherapy treatment and a display for observing information about the dose and viewing the dose or components of the dose.

Patent Number: 7,041,048 Issued on 05/09/2006 to Drobnik,   et al.


Inventors: Drobnik; Christopher D. (Wauconda, IL); Drobnik; Michael W. (Downers Grove, IL); Jones; Scott C. (Bloomingdale, IL); Sieracki; Dave (Elmhurst, IL)
Assignee: SourceTech Medical, LLC (Carol Stream, IL)
Appl. No.: 272803
Filed: October 16, 2002


Current U.S. Class: 600/7
Current International Class: A61N 5/00 (20060101)
Field of Search: 600/7,8,439,1,2-6,427,431,407,434,459 604/60,173,57,64,891.1,63,59,61,62 221/4 128/920,922 250/506.1,507.1 348/7


References Cited [Referenced By]

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Primary Examiner: Lacyk; John P.
Attorney, Agent or Firm: Patti & Brill, LLC

Claims



What is claimed is:

1. An apparatus, comprising: a housing; a holder in the housing that contains a dose of radioactive seeds corresponding to a treatment plan; a display for providing information for the dose according to the treatment plan; wherein the treatment plan comprises a plurality of radioactive seeds; wherein the housing comprises all of the plurality of radioactive seeds of the treatment plan; wherein the dose of radioactive seeds comprises a plurality of component doses; wherein each component dose comprises a needle load of one or more of the radioactive seeds; wherein the dose is ejected from the holder in the housing into one or more needles.

2. The apparatus of claim 1, wherein the dose is contained in the housing in an order corresponding to the treatment plan.

3. The apparatus of claim 1, wherein the housing allows ejection of the dose in an order corresponding to the treatment plan.

4. The apparatus of claim 1 wherein the housing allows ejection of the seeds from the housing in an order corresponding to spatial coordinates required by the treatment plan.

5. The apparatus of claim 4, wherein the treatment plan comprises a distribution pattern of the dose in a predetermined quantity of tissue.

6. The apparatus of claim 1, wherein the holder comprises a cylinder that receives the dose.

7. The apparatus of claim 6, wherein the cylinder comprises grooves in an outer surface thereof that receive the dose.

8. The apparatus of claim 7, wherein the grooves have a generally U shaped cross-section.

9. The apparatus of claim 7, wherein the grooves have a cross-section comprising a generally circular portion inwardly of the outer surface of the cylinder with a channel connecting the circular portion with the surface of the cylinder.

10. The apparatus of claim 7, further comprising a sleeve surrounding the cylinder thereby restraining the dose in the grooves of the cylinder.

11. The apparatus of claim 7, further comprising: a first gate at one end of the cylinder; a second grate at an opposed end of the cylinder; and wherein the first gate and the second gate restrain the dose within the grooves.

12. The apparatus of claim 11, wherein each of the first and second gates further comprises an elastomer.

13. The apparatus of claim 1, wherein the dose further comprises a plurality of component doses including at least one of discrete radioactive seeds and a continuous strand of radioactive seeds.

14. The apparatus of claim 1, wherein the information about the dose is an identity of one of the plurality of component doses.

15. The apparatus of claim 1, wherein the dose comprises a plurality of component doses and the holder comprises a cylinder having parallel grooves on a surface thereof with each groove receiving one of the plurality of component doses.

16. The apparatus of claim 15, further comprising a terminating member connected to an end of the housing, and the terminating member having a channel aligned selectively with each groove in the cylinder and adapted to be coupled to a needle.

17. The apparatus of claim 16, further comprising a wheel for rotating the cylinder for selective alignment of a selected one of the grooves with the channel in the terminating member.

18. The apparatus of claim 17, further comprising: a barrel connected to the wheel and the cylinder and wherein the barrel includes information associated with each of the plurality of components doses; a first display component that provides information about each of the plurality of component doses; a second display component that discloses a one of the component doses next to be ejected from the housing; and a lock member coupled to the wheel that secures the cylinder in a secured position for each of the plurality of component doses in association with the first display component and the second display component.

19. The apparatus of claim 17, further comprising: first and second gates located at opposed ends of the grooves for restraining movement of the dose within the grooves; and a stylus slidable through each gate of the first and second gates, the stylus contacting the dose to move the dose into the needle.

20. The apparatus of claim 1, further comprising a display that provides access to a sample of the dose for assaying the sample of the dose.

21. The apparatus of claim 1, wherein the housing comprises; a nose; a terminating member extending outwardly of the nose; and an engaging member connected to the nose that brings a needle in a coupled relationship with the terminating member.

22. The apparatus of claim 1, wherein at least a portion of the housing comprises a radiation shielding material.

23. The apparatus of claim 1, further comprising a display for observing the dose in the housing without radioactive exposure.

24. The apparatus of claim 23, wherein the dose is viewable through an element that is substantially impervious to radioactive transmission.

25. The apparatus of claim 24, wherein the dose is viewable indirectly through the element.

26. The apparatus of claim 23, wherein the dose is viewable through a light pipe to avoid radioactive exposure.

27. The apparatus of claim 23, wherein the dose is viewable through a prism to avoid radioactive exposure.

28. The apparatus of claim 23, wherein the dose is viewable through a combination of mirrors to avoid radioactive exposure.

29. The apparatus of claim 24, wherein the dose comprises a plurality of component doses, and wherein each component dose of the plurality of component doses is observable at the display.

30. The apparatus of claim 29, wherein each component dose of the plurality of component doses is observable prior to ejection according to the treatment plan.

31. The apparatus of claim 1, further comprising: a needle grid in the housing; and an adjustable indicator extending adjustably outwardly from the housing for measuring a distance between the housing and the needle grid and that allows a pre-selected distance of retraction of the housing to administer the dose at a predetermined location in a tissue.

32. The apparatus of claim 1, wherein the plurality of grooves retrains the dose of radioactive seeds.

33. The apparatus of claim 1, wherein the plurality of grooves are in a parallel relationship with each other and located at a surface of the cylinder, and wherein the cylinder is enclosed in a polycarbonate sleeve to retain the dose of radioactive seeds in the plurality of grooves.

34. The apparatus of claim 24, wherein the element comprises at least one of leaded glass and acrylic.

35. The apparatus of claim 1, wherein all of the plurality of radioactive seeds of the treatment plan are adminstered to a patient in a single medical procedure.

36. The apparatus of claim 1, wherein the housing is loaded with the plurality of radioactive seeds prior to shipment to a physician for administration of the plurality of radioactive seeds to the patient.

37. The apparatus of claim 1, wherein the information comprises spatial information.

38. The apparatus of claim 37, wherein the spatial information comprises rectangular spatial coordinates, three dimensional spatial coordinates, and/or a retraction distance associated with the dose.

39. The apparatus of claim 37, wherein the spatial information comprises rectangular coordinates and retraction distance associated with the dose.

40. An apparatus, comprising: a housing; a holder in the housing that contains a dose of radioactive seeds corresponding to a treatment plan; and wherein the treatment plan comprises a plurality of radioactive seeds; wherein the housing comprises all of the plurality of radioactive seeds of the treatment plan; wherein the dose is ejected from the housing; wherein the housing includes a sterilization passageway that allows sterilant to enter the housing for sterilization of the dose within the housing.

41. The apparatus of claim 40, wherein the sterilant comprises gamma radiation.

42. The apparatus of claim 40, wherein the sterilant comprises at least one of ethylene oxide gas and vaporized hydrogen peroxide.

43. The apparatus of claim 40, wherein the sterilant comprises pressurized steam.

44. A method, comprising the steps of: arranging within a housing a dose for distribution in tissue in an order corresponding to a treatment plan, wherein the order corresponds to spatial coordinates of the dose that corresponds to the treatment plan; administering the dose in the tissue from the housing in accordance with the treatment plan; and indicating on the housing spatial coordinates for the dose according to the treatment plan.

45. The method of claim 44, further comprising the step of generating a treatment plan for distribution of a dose.

46. The method of claim 44, further comprising the step of indicating on the housing an identity of the dose.

47. The method of claim 44, further comprising the steps of indicating on the housing a location of a grid for the administration of a dose.

48. The method of claim 44, further comprising the step of indicating on the housing a retraction distance for the dose.

49. The method of claim 44, further comprising the step of measuring a retraction distance of a dose in accordance with the treatment plan.

50. The method of claim 44, further comprising the step of including within the housing the dose corresponding to the treatment plan for one or more patients.

51. The method of claim 44, further comprising the step of indicating on the housing three-dimensional coordinates of each of a plurality of radioactive seeds of the dose as specified in the treatment plan.

52. The method of claim 44, further providing the step of observing information about the dose at the housing without radioactive exposure.

53. The method of claim 44, further comprising the step of displaying through the housing a sample of the dose for assaying.

54. The method of claim 44, wherein the step of arranging further comprises the steps of: arranging the dose in grooves on a cylinder in the housing; selectively aligning the grooves with a channel in a stalk connected to the housing; and moving at least a portion of the dose through the channel and into a needle aligned with the channel.

55. The method of claim 44, further comprising the step of controlling the housing with either a right hand or a left hand when administering the dose.

56. The method of claim 54, wherein the step of moving further comprises the step of moving the dose into tissue through the needle that is operatively coupled to the housing.

57. A method, comprising the steps of: arranging a plurality of component doses according to an order of the treatment plan; observing information about each of the plurality of component doses prior to ejection from the housing; and loading a plurality of needles with the dose from the housing according to the treatment plan; wherein the step of loading the plurality of needles with the dose from the housing according to the treatment plan comprises the steps of: aligning the dose with a gated aperture in the housing; moving the dose into the housing; and automatically sealing the gated aperture after the dose is loaded in the housing.

58. The method of claim 57, further comprising the steps of: engaging a hub of one of the plurality of needles to move the one of the plurality of needles in a coupled relationship with the housing; and ejecting a portion of the dose into the one of the plurality of needles.

59. The method of claim 58, wherein the step of ejecting further comprises the steps of: moving a stylus through a gate and through the housing to move the dose into a needle of the plurality of needles; and automatically sealing the gate upon withdrawal of the stylus.

60. The method of claim 57, wherein the step of loading further comprises the step of loading a dose that is a continuous strand.

61. The method of claim 60, wherein the strand comprises at least one radioactive seed.

62. The method of claim 57, further comprising the step of controlling the housing with either a right hand or a left hand when loading the needle with the dose.

63. An apparatus, comprising: a housing; a holder in the housing that receives a dose for a treatment positioned in an order corresponding to a treatment plan; a display on the housing and associated with the dose; wherein the dose is ejected from the housing; wherein the display comprises a first subcomponent display and a second subcomponent display; wherein the first subcomponent display provides information for the dose according to the treatment plan; wherein the second subcomponent display allows a user to indirectly view the dose without radioactive exposure.

64. The apparatus of claim 63, wherein the display is a slide button coupled to the housing and slidable between a first position and a second position and wherein in the first position, information about the dose is observable, and wherein in the second position access to the dose is provided to assay the dose.

65. The apparatus of claim 63, wherein the information about the dose comprises spatial information.

66. The apparatus of claim 63, wherein the dose comprises one of a plurality of component doses and the information comprises an identity of one of the plurality of component doses.

67. The apparatus of claim 63, wherein the dose that is observable at the second subcomponent display corresponds to an identity of the dose provided at the first subcomponent display.

68. The apparatus of claim 63, wherein the display has an access for assay of the dose.

69. The apparatus of claim 63, wherein the display comprises an element impervious to radioactive transmission; and wherein the dose is observable through a slot in the housing.

70. The apparatus of claim 63, wherein the dose associated with the display comprises a portion of a dose next in queue for ejection into a needle.

71. The apparatus of claim 64, wherein the display for access comprises a slide button that is slidably coupled to the housing, and wherein the slide button in a first restrained position provided access to assay the dose and in a second restrained position provides information about the dose.

72. The apparatus of claim 63, wherein the holder comprises: a cylinder having a channel for containing the dose; a barrel having a wheel and an end connected to the cylinder; and wherein the barrel is coupled to the housing in a sliding relationship.

73. The apparatus of claim 72, wherein the barrel contains information about the dose that is observable at the display.

74. The apparatus of claim 73, wherein the information is on a surface of the barrel and accessible at the display by selective rotation of the wheel for observing information about the dose.

75. The apparatus of claim 73, wherein the dose comprises a plurality of component doses, and wherein the information accessible at the display corresponds to a one of the plurality of component doses of the treatment plan.

76. The apparatus of claim 63, further comprises: the housing having a nose and a body, the nose of the housing extending from the body of the housing; a terminating member comprising a base operatively connected to the housing and selectively engageable with the holder to selectively position the barrel in alignment with the display for providing access to information associated with the dose; and a stalk extending away from the base and outwardly of an end of the nose; and wherein the stalk includes a channel aligned with the holder to receive a dose ejected from the housing.

77. The apparatus of claim 76, further comprising an engaging member connected to the end of the housing for engaging an end of a needle to bring it into coupled relationship with an end of the stalk.

78. The apparatus of claim 77, wherein the engaging member further comprises: an extendable connecting member; and an actuator that guides the extendable connecting member to engagement with an end of the needle.

79. The apparatus of claim 78, wherein extension of the extendable member moves the extendable member away from the needle and retraction of the extendable member converges a forked end of the extendable member upon the needle near a hub of the needle and draws the hub of the needle in a coupled relationship with the stalk.

80. The apparatus of claim 72, further comprising: an end cap connected to an end of the housing, the end cap having an annular shoulder extending inwardly of the end of the housing and relieving in a sliding coupled connection an end of the cylinder and a channel extending longitudinally through the end cap; and the channel in the end cap axially aligned with the channel in the cylinder and the channel in the stalk defining a pathway for loading the dose in the housing and ejecting the dose from the housing.

81. The apparatus of claim 80, further comprising: an automatically adjustable indicator extending longitudinally through the housing and having a thread end extending through the end cap and a spring biased extension member extending outwardly of an opposed end thereof and the nose of the housing to measure a retraction measurement associated with the dose.

82. The apparatus of claim 63, wherein the dose contained in the holder is positioned in an order corresponding to spatial coordinates of the dose that corresponds to the treatment plan.

83. The apparatus of claim 63, wherein the dose comprises a plurality of component doses, and wherein each dose of the plurality of component doses comprises a continuous linked strand having at least one radioactive seed and at least one spacer.

84. An apparatus, comprising: a housing configured to be handheld in either a left or right hand; a holder in the housing that contains a dose of radioactive seeds corresponding to a treatment plan; wherein the treatment plan comprises a plurality of radioactive seeds; wherein the housing comprises all of the plurality of radioactive seeds of the treatment plan; wherein the ejection of the dose from the housing is effected according to the treatment plan.

85. The apparatus of claim 84, further comprising a guide on a surface of the housing for receiving a hand positioned to control the housing when loading a needle with the dose.

86. The apparatus of claim 85, wherein the guide comprises a pair of tapered portions defining an opposed pair of areas on the surface of the housing for receiving either a left hand or a right hand; and wherein the apparatus further comprises an actuator on the housing positioned for engagement with either the right hand or the left hand for connecting the needle to the housing.

87. An apparatus, comprising: means for containing within a housing a plurality of component doses of radioactive seeds corresponding to a treatment plan, wherein the treatment plan comprises a plurality of radioactive seeds, wherein the housing comprises all of the plurality of radioactive seeds of the treatment plan; means for displaying information for the dose according to the treatment plan and the one of the plurality of component doses prior to ejecting the one of the plurality of doses from the housing; and means for ejecting one of the plurality of component doses from the housing.

88. The apparatus of claim 87, further comprising means for displaying information associated with the one of the plurality of component doses.

89. The apparatus of claim 87, further comprising means for restraining the plurality of component doses within the housing prior to and after ejecting the one of the plurality of component doses.

90. The apparatus of claim 87, wherein the means for ejecting comprises: means for aligning the one of the component doses in a pathway extending through the housing; and means for moving the one of the plurality of component doses through the pathway and out of the housing.

91. The apparatus of claim 90, comprising means for coupling the housing to a needle to receive the one of the plurality of component doses to be ejected from the housing.

92. The apparatus of claim 87, further comprising: means for configuring the housing to be hand held with either the right hand or the left hand; and means for controlling the housing with either the right hand or the left hand when connecting the housing to a needle and ejecting the one of the plurality of component doses from the housing.

93. The apparatus of claim 88, wherein the means for displaying information associated with the one of the plurality of component doses comprises: means for displaying an identity of the one of the plurality of component doses.

94. An apparatus, comprising: a housing; a holder in the housing that contains a dose of radioactive seeds and adapted for use in a brachytherapy treatment plan; wherein the holder comprises a cylinder having a plurality of grooves; wherein the dose is ejected from the housing; wherein the housing comprises a sterilization passageway that allows sterilant to enter the housing for sterilization of the dose within the housing.

95. An apparatus, comprising: a housing; a cylinder in the housing that contains a dose of radioactive seeds corresponding to a treatment plan, the dose comprising a plurality of component doses including at least one of discrete radioactive seeds and a continuous strand of radioactive seeds; the cylinder having a grooves in an outer surface thereof receive the dose; a sleeve surrounding the cylinder, the sleeve restraining the dose in the grooves of the cylinder; a first gate at a first end of the cylinder and a second gate at a second end of the cylinder opposed from the first end of the cylinder, the first gate and the second gate restraining the dose within the grooves; a terminating member connected to the first end of the housing, the terminating member having a channel aligned selectively with each groove in the cylinder and adapted to be coupled to at least one needle; a first display component that provides spatial information for each of the plurality of component doses according to the treatment plan; a second display component that discloses a one of the component doses next to be ejected from the housing.

96. An apparatus, comprising: a housing; a cylinder in the housing that contains a dose of radioactive seeds corresponding to a treatment plan, the dose comprising a plurality of component doses including at least one of discrete radioactive seeds and a continuous strand of radioactive seeds; the cylinder having grooves in an outer surface thereof that receive the dose; a sleeve surrounding the cylinder, the sleeve retraining the dose in the grooves of the cylinder; a first gate at a first end of the cylinder and a second gate a second end of the cylinder opposed from the first end of the cylinder, the first gate and the second gate retraining the dose within the grooves; a terminating member connected to the first end of the housing, the terminating member having a channel aligned selectively with each groove in the cylinder and adapted to be coupled to at least one needle; a wheel for rotating the cylinder to effect selective alignment of a selected one of the grooves with the channel in the terminating member; a barrel connected to the wheel and the cylinder, the barrel having information associated with each of the plurality of component doses; a first display component that provides information about each of the plurality of component doses; a second display component that discloses a one of the component doses next to be ejected from the housing; and a lock member coupled to the wheel that secures the cylinder in a secured position for each of the plurality of component doses in association with the first display component and the second display component.

97. A method, comprising the steps of: arranging in a housing a dose of radioactive seeds according to a treatment plan; and loading a plurality of needles with the dose from the housing according to the treatment plan; arranging a plurality of component doses according to an order of the treatment plan; and observing information about each of the plurality of component doses prior to ejection from the housing; engaging a hub of one of the plurality of needles to move the one of the plurality of needles in a coupled relationship with the housing; and moving a stylus through a gate and through the housing to move the dose into a needle of the plurality of needles; and automatically sealing the gate upon withdrawal of the stylus ejecting a portion of the dose into the one of the plurality of needles.

98. A method, comprising the steps of: moving, according to a treatment plan, a dose of radioactive seeds into a housing via a gated aperture, the dose including radioactive seeds and spacers in continuous strands; automatically sealing the gated aperture after the dose is loaded in the housing; assaying the radioactivity of at least one of the radioactive seeds to verify a correct arrangement of the dose in the housing according to the treatment plan; and visually inspecting the dose via a display in the housing to verify a correct arrangement of the dose in the housing according to the treatment plan.

99. The method of claim 57, wherein the step of observing information about each of the plurality of component doses prior to ejection from the housing comprise the step of: observing an identity of one of the plurality of component doses prior to ejection from the housing.
Description



BACKGROUND

Bodily cancers are commonly treated using radiation therapy, which employs radiation to kill cancer cells. One form of radiation therapy is brachytherapy. The treatment of brachytherapy places the source of radiation in direct contact with the afflicted tissue. A common brachytherapy treatment is the implantation of radioactive seeds in the prostate gland to kill prostate cancer cells. The physician employs tools such as ultrasounds, computerized axial tomography ("CAT") scans, and X-ray images in concert with dose-planning computer software programs to evaluate the medical condition of the patient. The physician constructs an optimal treatment plan to evenly distribute radiation throughout the tissue. Proper seed placement is important for controlling the distribution of radiation evenly throughout the entire prostate gland. Placing the radioactive seeds too close together may result in a portion of the prostate receiving too much radiation. Not placing enough seeds in portions of the tissue may result in a region in which the strength of the radiation is insufficient to kill cancer cells.

The physician may insert seeds of the same or different radioactive strengths in pre-selected locations of the tissue. The seeds are inserted into the tissue through an implantation needle, also known as a brachytherapy needle. Multiple brachytherapy needles are required to insert the seeds into multiple locations of the tissue. Each brachytherapy needle inserts a plurality of seeds. An average brachytherapy treatment involves the implantation of approximately 80 to 100 seeds. One way physicians can achieve the axial seed-to-seed spacing required by the treatment plan is to place non-radioactive spacers between the radioactive seeds.

One technique for implanting the seeds involves manually loading the seeds one by one into brachytherapy needles along with spacers in the order prescribed by the treatment plan. The physician then inserts a loaded brachytherapy needle into a specific area of tissue to be treated. A pushrod is guided into the channel of the brachytherapy needle. The physician withdraws the brachytherapy needle while holding the pushrod in place. The seeds are pushed out of the needle and remain inside the afflicted tissue. Multiple rows of seeds and spacers are used to treat an area of tissue, with each position in a row requiring a different brachytherapy needle loaded with seeds and spacers as specified by the physician's plan. Most treatment plans require twenty or more needles loaded with various combinations of seeds and spacers. The management of twenty or more loaded needles presents organizational and management issues associated with the handling of such a large number of needles and includes the inherent risk of handling radioactive materials.

Needles which are loaded prior to the operation must be plugged to prevent the seeds from spilling out during transport or operating room setup. The needles themselves provide limited radiation shielding, requiring the needles to be packaged in a shielded container once loaded.

To place the seeds in the tissue according to the physician's plan, the needle may be releasably attached to a fixed base member (template). The needle is movable within a plurality of positions with respect to the base member with the plurality of positions corresponding to the locations in which the physician desires placement of the seeds and spacers. Those skilled in the art will understand the use of templates and needle grids in the administration treatments in brachytherapy.

The seeds and spacers are small and difficult to handle. The radioactive seeds are a hazardous material and prolonged contact with the needles containing the radioactive seeds is not desirable. Loading seeds and spacers into the individual brachytherapy needles is a time consuming process that increases the time that the medical staff is exposed. The needle loading process must be repeated for each needle used in the treatment. After the needles are loaded, identifying the arrangement of seeds and spacers in the needle and the strength of the seeds requires that the needles be unloaded, inspected, and reloaded. The loaded needles require a shielded container for transport. The seeds may also fall out of the needle, for example due to plug failure. This causes the medical staff to locate, reload, and resterlize the radioactive seeds. Repeated handling of the radioactive seeds by the medical staff increases exposure time.

A technique exists using cartridges to insert the seeds and spacers into the brachytherapy needle. The seeds and spacers are placed in the desired order in a cartridge, which then detachably couples to the brachytherapy needle. The physician then transfers the seeds and spacers from the cartridge into the brachytherapy needle and removes the cartridge from the needle. The brachytherapy needle can then either be loaded into a shielded transport container or, if loaded in the operating room, inserted directly into the afflicted tissue. The physician guides the pushrod into the channel of the brachytherapy needle. The physician then slowly withdraws the brachytherapy needle while holding the pushrod in place. The seeds are pushed out of the needle and remain in a row inside the afflicted tissue. Multiple rows of seeds and spacers are commonly used to treat an area of tissue. Each position in a row requires a different cartridge preloaded to match the treatment plan parameters, requiring the medical staff to handle a different cartridge for each needle used.

One technique involves placing all of the radioactive seeds in a cartridge and manually injecting the seeds in the patient during a treatment. The spacing of the seeds is achieved by withdrawing the needle and injecting the seeds at spaced intervals as the needle is withdrawn. The spacing of the seeds is achieved manually without the benefit of any spacers.

Another technique exists for ensuring proper seed placement and distribution. The radioactive seeds are coupled to form a chain. The manufacturer provides the physician with assembled chains of ten seeds separated by standard spacing. Each chain arrives in a shielded package. The physician removes the chain from the shielded packaging. The physician cuts the chain to match the prescribed treatment plan. Each cut chain is then loaded into an individual brachytherapy needle. The brachytherapy needle inserts into the afflicted tissue. The physician guides the pushrod into the channel of the brachytherapy needle. The physician then slowly withdraws the brachytherapy needle while the holding the pushrod in place. The seed chain is pushed out of the needle and remains in the afflicted tissue. Multiple chains of seeds are used to treat an area of tissue. Each chain must be implanted individually in a different location of the tissue. The physician spends additional time manipulating each individual chain increasing exposure time to the radioactive seeds.

SUMMARY

An apparatus and method for administering a dose in brachytherapy comprising a handheld housing having a holder containing a dose of radioactive seeds adapted for use in a brachytherapy treatment and a display for observing information about the dose and viewing the dose or components of the dose. The display identifies and provides information about the dose and a component of a dose. A port provides access to the dose for assay. The display provides a visual display of the dose and components of the dose. A dose is loaded directly into a holder in the housing, needles are coupled to the housing and the dose is injected into the needle from the housing.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 is an example of a needle-loading plan;

FIG. 2 is a graphical representation of a needle placement in a template;

FIG. 3 is a chart illustrating seeds in each corresponding needle;

FIG. 4 is a is a perspective view of an apparatus in accordance with an example of the invention;

FIG. 5 is a top view of an apparatus in accordance with an example of the invention;

FIG. 6 is a side view of an apparatus in accordance with an example of the invention;

FIG. 7 is a is a rear view of an apparatus in accordance with an example of the invention;

FIG. 8 is a front view of an apparatus in accordance with an example of the invention;

FIGS. 9 and 10 are a perspective views showing phantom hands with an apparatus in accordance with an example the invention;

FIG. 11 is a section view along 11 11' shown in FIG. 5 of an apparatus in accordance with an example of the invention;

FIG. 12 is an exploded view of an apparatus in accordance with an example of the invention;

FIG. 13 is a view of a holder of the apparatus in accordance with an example of the invention;

FIGS. 14 and 15 are top views of a display of the apparatus in accordance with an example of the invention;

FIG. 16 is a section view along 16 16' shown in FIG. 13 of the apparatus in accordance with an example of the invention;

FIGS. 17 and 18 are cross sections of grooves of a cylinder of the apparatus in accordance with an example of the invention;

FIG. 19 is a cross sectional view along 19 19' shown FIG. 5 of the apparatus in accordance with an example of the invention;

FIG. 20 is another example of the cross section of FIG. 18 of an apparatus in accordance with another example of the invention;

FIG. 21 is a front view along the line 21 21' as shown in FIG. 13 of an apparatus in accordance with an example of the invention;

FIG. 22 is a view along the line 22 22' as shown in FIG. 12 of an apparatus in accordance with an example of the invention;

FIG. 23 is a partial view of loading the apparatus in accordance with an example of the invention;

FIGS. 24 and 25 depict side views of an engaging member of an apparatus in accordance with the invention; and

FIG. 26 is a front view along the line 26 26' shown in FIG. 24 of an apparatus in accordance with an example of the invention.

DETAILED DESCRIPTION

In the administration of a brachytherapy treatment the administration of a dose of radioactive seeds is performed in accordance with a treatment plan prepared by a physician for a patient. The treatment plan represents the desired distribution pattern for a plurality of radioactive seeds in the afflicted tissue. The physician employs medical tools such as ultrasound imaging, computerized axial tomography ("CAT") scans, and X-ray imaging in concert with dose-planning computer software programs for evaluating the medical condition of the patient. Each patient's tissue varies in size, shape, and location. The present stage of cancer in the afflicted tissue may also vary.

The treatment plan references a template corresponding to the patient's afflicted tissue. This allows the physician to determine ideal implant locations and indicate them on the template. Each implant location is denoted on the template with a figure, along with information regarding the depth of the needle and the quantity of seeds for that specific implant location. The implant locations are also numbered for reference before and during the operation. The physician compiles the information from the template to form a chart listing each needle and the desired location, retraction depth, and quantity of implant seeds for each needle. Another chart illustrating the seed and spacer layout in each individual needle is also prepared. The physician uses this information in the preparation of a brachytherapy treatment device and during the operation.

An example needle-loading table 102 of FIG. 1 comprises columns of data correlating a needle number 104, a needle retraction 106, a needle hole location 108, and a quantity of seeds 110. A typical procedure requires approximately twenty needles. The needle retraction 106 is the distance the needle should be withdrawn from the innermost point of the tissue. The hole location 108 designates the implant location in the afflicted tissue. The needle-loading table 102 also lists the quantity of seeds 110 to be implanted in each hole.

A chart 112 illustrating a graphical representation of the needle placement in a template is shown in FIG. 2. A scale 116 along the y-axis and a scale 118 along the x-axis define a specific needle hole position 114. A legend 122 correlates each geometric figure at the hole location 114 with a given retraction depth. A superscript with each geometric figure provides the needle number 104, and the number of seeds 110 contained in each needle 104 is within the geometric figure.

A chart 124 illustrating the seeds in each corresponding needle is shown in FIG. 3. A scale along the needle illustration represents the retraction depth. The pharmacist or physician employs the chart 124 for laying out the proper seed dosage prior to the operation. The physician employs non-radioactive spacers to maintain the distances between the seeds. Specially loaded needles are denoted on the correlating table with a small black circle next to the needle number. A special loaded needle is one that requires multiple adjacent spacers or spacing of non-standard lengths.

Referring to FIGS. 4 through 12, an apparatus 130 is shown in accordance with an example of the invention comprising a housing 134 having two mating sections 135 and 136, a nose 137 extending from a first end 138 of the housing 134. A guide 140 is located at a second end 142 of the housing 134. The guide 140 comprises a pair of tapered raised portions 143 and 144 extending toward the first end 138 of the housing 134. The guide 140 assists in controlling the apparatus 130 with either a right hand or a left hand during the operation of the apparatus 130 by the physician.

The housing 134 is comprised of radiation shielding material. For example, the housing 134 may comprise stainless steel or lead. In another example, the housing 134 comprises a "loaded" plastic. The "loaded" plastic is a plastic that is mixed with materials with radiation shielding characteristics, yielding a plastic with similar radiation shielding characteristics, such as the Ecomass compounds available from PolyOne Corporation (www.ecomass.com). In one example, the housing 134 comprises 0.100'' thick "loaded" plastic made up of nylon 12 mixed with approximately 33% by volume bismuth subcarbonate.

In another example of the invention, the housing 134 may further comprise a plurality of apertures (not shown) connected to the radioactive seeds. To avoid radioactive exposure the apertures do not provide a direct line of sight to the radioactive seeds. The radioactive seeds may then be exposed to a sterilizing while in the housing 134. The sterilizing agent may be gamma radiation, pressurized steam, ethylene oxide gas or vaporized hydrogen peroxide.

A display 148 is located on the surface of the housing 134. The display 148 comprises: a first subcomponent display 149, such as a slide button coupled with the housing 134, that provides information about the dose contained within the housing 134; a port to assay a sample of the dose; and a second subcomponent 150 to view the dose or all of the components of the dose, including the dose or component of the dose next to be ejected from the apparatus 130.

A terminating member 154 has a base member 155, located within the housing 134, and a stalk 156 extending outward of the nose 137. An engaging member 158 is connected to the nose 137. The engaging member 158 is operated by an actuator 160. The engaging member 158 has an extendable member 164 that is moved outwardly and inwardly of the nose 137 by the operation of the actuator 160. As will be explained, an end 166 of the extendable member 164 engages a needle and moves the needle into a coupled relationship with the stalk 156.

An adjustable indicator 168 has a body portion 169 located within the housing 134. A collar 173 abuts the base member 155 of the terminating member 154. A spring biased extension member 170 extends outwardly of the nose 137. As shown in FIG. 6, a stop member 172 restrains the spring biased extension member 170 in a compressed position. The extension member 170 has a forked end 174 that is positioned adjacent to the stalk 156. Those skilled in the art will be familiar with stop structures that may be used as stop members to hold a member from moving against a spring bias.

In a fully extended or unrestrained mode, the extension member 170 extends outwardly with the forked end 174 in contact with a needle grid to make a measurement to position the dose in the correct location in tissue. In one example of the invention, the physician knows the retraction distance and moves the housing 134 toward or away from the needle grid until the correct retraction measurement is indicated usually in centimeters on the adjustable indicator 168. The physician may then begin the administration of the dose in the tissue.

In another example of the invention, the extension member 170 of the adjustable indicator is manually extended outwardly at fixed intervals, for example, in one-half centimeter intervals. The physician then manually extends and fixes the extension member 170 to the required retracted distance for the dose, places the forked end 174 in contact with the needle grid and administers the dose.

A holder 180 as shown in FIG. 13 has a cylinder 181 and a barrel 183 connected to an end of the cylinder 181. The cylinder 181 has parallel grooves 184. A cross-section of the cylinder 181 is shown in FIG. 16. Referring to FIG. 17, the grooves 184 have a U-shaped cross-section. In another example, shown in FIG. 18, each of the grooves has a semi-circular cross-section and a channel 187 connecting the groove to the surface of the cylinder 181.

In one example of the invention as shown in FIG. 16, the cylinder 181 has 36 grooves. A polycarbonate sleeve 182 surrounds the cylinder 181. The polycarbonate sleeve 182 serves to retain the seeds and spacers in the grooves 184. In a treatment plan, the grooves 184 in the cylinder 181 may be occupied with the dose or a plurality of component doses of the treatment plan. The component doses may each include a combination of radioactive discrete seeds and spacers, or stranded doses comprised of a continuous strand of radioactive seeds and spacers. The remaining grooves may be left unoccupied or used for a dose of radioactive seeds not included in the treatment plan to be used at the physician's discretion.

Referring additionally to FIG. 13, the barrel 183 has slots 188 extending inwardly from an end 189 of the barrel 183. An indexing wheel 190 is connected to the holder 180 having a knurled edge 191 projecting beyond an exterior surface of the housing 134. The indexing wheel 190 has projections 192 that couple with the slots 188 in the barrel 183.

An end cap 193 has an annular end 196 that is slidably coupled with an inner surface 197 of an end of the cylinder 181. When the holder 180 is coupled within the housing 134, the indexing wheel 190 engages and rotates the barrel 183 rotating the holder 180 and the cylinder 181 with the end of the cylinder 181 rotating about the annular end 196 of the end cap 193.

A threaded connector 199 holds the end cap 193 abutted to the housing 134. The end cap 193 is held in the abutting relationship with the housing 134 because of the threaded connection of the end cap 193 with a threaded portion 200 of the adjustable indicator 168. Referring to FIG. 11, the collar 173 of the adjustable indicator 168 abuts the base 155 (see FIG. 12) and restrains the adjustable indicator 168 and an opposed end at an interface 175.

An annular threaded connector 201 and fasteners 202 connect the two mating sections 135 and 136 of the housing 134.

As shown in FIG. 13, the cylinder 181 includes a plurality of parallel grooves 184. In one example of the invention, the grooves 184 are in the surface of the cylinder 181. In one example of the invention, the dose in accordance with the treatment plan comprises a plurality of component doses and each groove of the parallel grooves 184 may contain one of the plurality of component doses.

Referring to FIG. 13, a surface 151 of the barrel 183 includes information about each of the plurality of component doses that corresponds to the treatment plan. The information may include a specific number or identity of the component dose, the spatial rectangular or three dimensional coordinates of the dose, and the retraction distance.

In FIG. 14, the first subcomponent display 149 is shown positioned toward the first end 138 of the housing 134, and the information shown at the first subcomponent display 150 is 23, D4.5, R 2.5, where 23 is the number or identity of one of the plurality of the component doses, D4.5 represents the spatial coordinates on the needle grid and 2.5 is the retraction distance usually specified in centimeters.

In FIG. 15, the first subcomponent 149 is shown positioned toward the second end 142 of the housing 134. In this position, a sample of the dose identified by dose number


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