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Device and method for treatment of wounds with nitric oxide Number:7,520,866 from the United States Patent and Trademark Office (PTO) owispatent

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Title: Device and method for treatment of wounds with nitric oxide

Abstract: Topical exposure of nitric oxide gas to wounds such as chronic non-healing wounds may be beneficial in promoting healing of the wound and in preparing the wound bed for further treatment and recovery. Nitric oxide gas may be used, for example, to reduce the microbial infection and burden on these wounds, manage exudate secretion by reducing inflammation, upregulate expression of endogenous collagenase to locally debride the wound, and regulate the formation of collagen. High concentration of nitric oxide ranging from about 160 to 400 ppm may be used without inducing toxicity in the healthy cells around a wound site. Additionally, exposure to the high concentration for a first treatment period reduces the microbial burden and inflammation at the wound site and increase collagenase expression to debride necrotic tissue at the wound site. After a first treatment period with high concentration of nitric oxide, a second treatment period at a lower concentration of nitric oxide preferably ranging from about 5-20 ppm may to provided to restore the balance of nitric oxide and induce collagen expression to aid in the closure of the wound.

Patent Number: 7,520,866 Issued on 04/21/2009 to Stenzler,   et al.

Inventors: Stenzler; Alex (Long Beach, CA), Miller; Chris C (North Vancouver, CA)
Assignee: Sensormedics Corporation (Yorba Linda, CA)
Pulmonox Technologies Corporation (Edmonton, Alberta, CA)
Appl. No.: 11/487,600
Filed: July 13, 2006

Related U.S. Patent Documents
Application NumberFiling DatePatent NumberIssue Date
11021109Dec., 20047122018
10944479Sep., 2004
10615546Jul., 2003
10172270Jun., 20026793644
09749022Dec., 20006432077
60431876Dec., 2002
60409400Sep., 2002
60394690Jul., 2002

Current U.S. Class: 604/23 ; 424/718; 604/289; 604/290; 604/540; 604/543
Current International Class: A61M 37/00 (20060101); A01N 59/02 (20060101); A61M 1/00 (20060101)
Field of Search: 604/23,290,25,543,540,289 424/718 514/579,645

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