Senior Fitness - Exercise and Nutrition for Aging Men and Women
FREE Article Feed for your website.
Bio-Medical Research Article Database
Informative Articles on Life, Love and Happiness
Tutorials on Business to Writing
Famous Quotes from Famous People
Song Lyric Information
New US Patent Information
Comprehensive List of Content by Category
Online Auctions and Shopping Related Articles
Article Search
Most Recent Articles

Multiple CPG oligodeoxynucleotides and their use to induce an immune response Number:7,521,063 from the United States Patent and Trademark Office (PTO) owispatent

Home    Author Login    Submit Article    Article Search    Add Your Link    Edit Your Link    Contact Us    Advertising    Disclaimer

   

Google
 

Top Breaking News
     Anger Erupts in Athens as Bailout Demands Spark Outrage by VOA News
     Zuma’s Plan for South Africa Wins Support by Delia Robertson
     Obama, Chinese Vice President to Meet at White House by Dan Robinson

Title: Multiple CPG oligodeoxynucleotides and their use to induce an immune response

Abstract: Compositions including multiple oligodeoxynucleotides with a CpG motif are disclosed herein. The compositions can include either D or K type oligodeoxynucleotides. These compositions are of use in inducing an immune response in a large percentage of the individuals in a population.

Patent Number: 7,521,063 Issued on 04/21/2009 to Klinman,   et al.

Inventors: Klinman; Dennis (Potomac, MD), Ishii; Ken (Columbia, MD), Verthelyi; Daniela (Potomac, MD)
Assignee: The United States of America as represented by the Department of Health and Human Services (Washington, DC)
N/A (
Appl. No.: 10/194,035
Filed: July 12, 2002

Related U.S. Patent Documents
Application NumberFiling DatePatent NumberIssue Date
PCT/US01/01122Jan., 2001
60176115Jan., 2000

Current U.S. Class: 424/282.1 ; 424/278.1; 424/280.1; 514/44R
Current International Class: A61K 45/00 (20060101)
Field of Search: 424/130.1,133.1,1.11,1.53,1.57,1.65 435/6,91.1,91.7,458,455,328 536/23.1 530/300

References Cited [Referenced By]
U.S. Patent Documents
2215233 September 1940 Ruskin
3906092 September 1975 Hilleman et al.
3911117 October 1975 Ender
3914450 October 1975 Robbins et al.
4469863 September 1984 Ts'o et al.
4544559 October 1985 Gil et al.
4741914 May 1988 Kimizuka et al.
4758553 July 1988 Ogoshi
4806376 February 1989 Saeki et al.
4956296 September 1990 Fahnestock
4963387 October 1990 Nakagawa et al.
4994442 February 1991 Gil et al.
5023243 June 1991 Tullis
5066500 November 1991 Gil et al.
5231085 July 1993 Alexander et al.
5234811 August 1993 Beutler et al.
5248670 September 1993 Draper et al.
5268365 December 1993 Rudolph et al.
5288509 February 1994 Potman et al.
5488039 January 1996 Masor et al.
5492899 February 1996 Masor et al.
5585479 December 1996 Hoke et al.
5591721 January 1997 Agrawal et al.
5602109 February 1997 Masor et al.
5612060 March 1997 Alexander
5614191 March 1997 Puri et al.
5650156 July 1997 Grinstaff et al.
5663153 September 1997 Hutcherson et al.
5679397 October 1997 Kuroda et al.
5684147 November 1997 Agrawal et al.
5700590 December 1997 Masor et al.
5712256 January 1998 Kulkarni et al.
5723335 March 1998 Hutcherson et al.
5786189 July 1998 Loct et al.
5804566 September 1998 Carson et al.
5840705 November 1998 Tsukuda
5849719 December 1998 Carson et al.
5895652 April 1999 Giampapa
5919456 July 1999 Puri et al.
5922766 July 1999 Acosta et al.
5976580 November 1999 Ivey et al.
5980958 November 1999 Naylor et al.
5994126 November 1999 Steinman et al.
6022853 February 2000 Kuberasampath et al.
6194388 February 2001 Krieg et al.
6207646 March 2001 Krieg et al.
6214806 April 2001 Krieg et al.
6218371 April 2001 Krieg et al.
6239116 May 2001 Krieg et al.
6339068 January 2002 Krieg et al.
6406705 June 2002 Davis et al.
6423539 July 2002 Fong et al.
6428788 August 2002 Debinski et al.
6429199 August 2002 Krieg et al.
6498148 December 2002 Raz
6514948 February 2003 Raz et al.
6534062 March 2003 Krieg et al.
6552006 April 2003 Raz et al.
6562798 May 2003 Schwartz
6589940 July 2003 Raz et al.
6610661 August 2003 Carson et al.
6613751 September 2003 Raz et al.
6653292 November 2003 Krieg et al.
2001/0034330 October 2001 Kensil
2001/0036462 November 2001 Fong et al.
2001/0044416 November 2001 McCluskie et al.
2001/0046967 November 2001 Van Nest
2002/0006403 January 2002 Yu et al.
2002/0028784 March 2002 Van Nest
2002/0042383 April 2002 Yew et al.
2002/0042387 April 2002 Raz et al.
2002/0055477 May 2002 Van Nest et al.
2002/0064515 May 2002 Krieg et al.
2002/0065236 May 2002 Yew et al.
2002/0086295 July 2002 Raz et al.
2002/0086839 July 2002 Raz et al.
2002/0090724 July 2002 Taylor et al.
2002/0091095 July 2002 Phillips et al.
2002/0091097 July 2002 Bratzler et al.
2002/0098199 July 2002 Van Nest et al.
2002/0098205 July 2002 Choi et al.
2002/0098980 July 2002 Choi et al.
2002/0107212 August 2002 Van Nest et al.
2002/0110569 August 2002 Granoff et al.
2002/0111323 August 2002 Martin et al.
2002/0136776 September 2002 Fang et al.
2002/0137714 September 2002 Kandimalla et al.
2002/0142974 October 2002 Kohn et al.
2002/0142977 October 2002 Raz et al.
2002/0142978 October 2002 Raz et al.
2002/0156033 October 2002 Bratzler et al.
2002/0164341 November 2002 Davis et al.
2002/0165178 November 2002 Schetter et al.
2002/0183272 December 2002 Johnston et al.
2002/0197269 December 2002 Lingnau et al.
2002/0198165 December 2002 Bratzler et al.
2003/0003579 January 2003 Kadowaki et al.
2003/0022849 January 2003 Chang
2003/0022852 January 2003 Van Nest et al.
2003/0026782 February 2003 Krieg
2003/0026801 February 2003 Weiner et al.
2003/0049266 March 2003 Fearon et al.
2003/0050261 March 2003 Krieg et al.
2003/0050263 March 2003 Krieg et al.
2003/0050268 March 2003 Krieg et al.
2003/0052839 March 2003 Binley et al.
2003/0055014 March 2003 Bratzler
2003/0059773 March 2003 Van Nest et al.
2003/0060440 March 2003 Klinman et al.
2003/0064064 April 2003 Dina
2003/0072762 April 2003 Van de Winkel et al.
2003/0073142 April 2003 Chen et al.
2003/0078223 April 2003 Raz et al.
2003/0091599 May 2003 Davis et al.
2003/0092663 May 2003 Raz
2003/0096417 May 2003 Fischer
2003/0100527 May 2003 Krieg et al.
2003/0104044 June 2003 Semple et al.
2003/0104523 June 2003 Lipford et al.
2003/0109469 June 2003 Carson et al.
2003/0119773 June 2003 Raz et al.
2003/0119774 June 2003 Foldvari et al.
2003/0119776 June 2003 Phillips et al.
2003/0125284 July 2003 Raz et al.
2003/0129251 July 2003 Van Nest et al.
2003/0130217 July 2003 Raz et al.
2003/0133988 July 2003 Fearon et al.
2003/0135875 July 2003 Ehrhardt et al.
2003/0138413 July 2003 Vicari et al.
2003/0138453 July 2003 O'Hagan et al.
2003/0139364 July 2003 Krieg et al.
2003/0143213 July 2003 Raz et al.
2003/0143743 July 2003 Schuler et al.
2003/0144229 July 2003 Klinman et al.
2003/0147870 August 2003 Raz et al.
2003/0148316 August 2003 Lipford et al.
2003/0148976 August 2003 Krieg et al.
2003/0148983 August 2003 Fontoura et al.
2003/0157717 August 2003 Draghia-Akli
2003/0158136 August 2003 Rice et al.
2003/0165478 September 2003 Sokoll
2003/0166001 September 2003 Lipford
2003/0170273 September 2003 O'Hagan et al.
2003/0171321 September 2003 Schmidt et al.
2003/0175731 September 2003 Fearon et al.
2003/0176373 September 2003 Raz et al.
2003/0176389 September 2003 Raz et al.
2003/0180320 September 2003 Darju et al.
2003/0181406 September 2003 Schetter et al.
2003/0185848 October 2003 Johnston et al.
2003/0185900 October 2003 Choi et al.
2003/0186921 October 2003 Carson et al.
2003/0191079 October 2003 Krieg et al.
2003/0199466 October 2003 Fearon et al.
2003/0203861 October 2003 Carson et al.
2003/0206967 November 2003 Choi et al.
2003/0207287 November 2003 Short
2003/0212026 November 2003 Krieg et al.
2003/0212028 November 2003 Raz et al.
2003/0216340 November 2003 Van Nest et al.
2003/0219752 November 2003 Short
2003/0220277 November 2003 Yew et al.
2003/0224010 December 2003 Davis et al.
2003/0225016 December 2003 Fearon et al.
2003/0232780 December 2003 Carson et al.
2004/0005588 January 2004 Cohen et al.
2004/0006010 January 2004 Carson et al.
2004/0006032 January 2004 Lopez
2004/0006034 January 2004 Raz et al.
2004/0009897 January 2004 Sokoll
2004/0009942 January 2004 Van Nest
2004/0009949 January 2004 Krieg
2004/0013686 January 2004 Granoff et al.
2004/0013688 January 2004 Wise et al.
2004/0028693 February 2004 Wu et al.
Foreign Patent Documents
0 286 224 Oct., 1988 EP
0 302 758 Nov., 1989 EP
0 468 520 Jan., 1991 EP
0 092 574 Apr., 1992 EP
0 572 735 Dec., 1993 EP
0 855 184 Jul., 1998 EP
1 198 249 Apr., 2002 EP
WO 91/12811 Sep., 1991 WO
WO 92/03458 Apr., 1992 WO
WO 92/18522 Oct., 1992 WO
WO 92/21353 Dec., 1992 WO
WO 93/17115 Sep., 1993 WO
WO 94/19945 Sep., 1994 WO
WO 95/05853 Mar., 1995 WO
WO 95/18231 Jul., 1995 WO
WO 95/26204 Oct., 1995 WO
WO 96/02555 Feb., 1996 WO
WO 96/24380 Feb., 1996 WO
WO 96/35782 Nov., 1996 WO
WO 97/28259 Jan., 1997 WO
WO 97/28259 Aug., 1997 WO
WO 98/29430 Dec., 1997 WO
WO 98/11211 Mar., 1998 WO
WO 98/14210 Apr., 1998 WO
WO 98/16247 Apr., 1998 WO
WO 98/18810 May., 1998 WO
WO 98/32462 Jul., 1998 WO
WO 98/37919 Sep., 1998 WO
WO 98/40100 Sep., 1998 WO
WO 98/49288 Nov., 1998 WO
WO 98/49348 Nov., 1998 WO
WO 98/52581 Nov., 1998 WO
WO 98/55495 Dec., 1998 WO
WO 99/11275 Mar., 1999 WO
WO 99/37151 Jul., 1999 WO
WO 99/51259 Oct., 1999 WO
WO 99/56755 Nov., 1999 WO
WO 99/58118 Nov., 1999 WO
WO 99/61056 Dec., 1999 WO
WO 99/62923 Dec., 1999 WO
WO 00/06588 Feb., 2000 WO
WO 00/14217 Mar., 2000 WO
WO 00/20039 Apr., 2000 WO
WO 00/21556 Apr., 2000 WO
WO 00/06588 Oct., 2000 WO
WO 00/61151 Oct., 2000 WO
WO 00/62787 Oct., 2000 WO
WP 00/62787 Oct., 2000 WO
WO 0/67023 Nov., 2000 WO
WO 00/67023 Nov., 2000 WO
WO 00/67787 Nov., 2000 WO
WO 00/00232 Jan., 2001 WO
WO 01/00232 Jan., 2001 WO
WO 01/02007 Jan., 2001 WO
WO 01/12223 Feb., 2001 WO
WO 01/12804 Feb., 2001 WO
WO 01/22990 Apr., 2001 WO
WO 01/51500 Jul., 2001 WO
WO 0151500 Jul., 2001 WO
WO 01/55341 Aug., 2001 WO
WO 01/68077 Sep., 2001 WO
WO 01/68103 Sep., 2001 WO
WO 01/68116 Sep., 2001 WO
WO 01/68117 Sep., 2001 WO
WO 02/69369 Sep., 2002 WO

Other References

US 6,008,200, 12/1999, Krieg (withdrawn) cited by other .
U.S. Appl. No. 60/156,135. cited by examiner .
Krieg et al., CpG motif in bacterial DNA and their immune effects. Annu. Rev. Immunol., 2002, vol. 20, 709-760. cited by examiner .
Mutwiri et al. Biological activity of immunostimulatory CpG DNA motifs in domestic animals. Veterinary Immunology and Immunopathology, 2003, vol. 91, 89-103. cited by examiner .
Alama et al., "Antisense Oligonucleotides as Therapeutic Agents," Pharmacol. Res. 36: 171-178 (1997). cited by other .
Ballas et al., "Induction of NK Activity in Murine and Human Cells by CpG Motifs in Oligodeoxynucleotides and Bacterial DNA," J. Immun. 157: 1840-1845 (1996). cited by other .
Klinman et al., "CpG Motifs Present in Bacterial DNA Rapidly Induce Lymphocytes to Secrete Interleukin 6, Interleukin 12 and Interferon .gamma.," Proc. Natl. Acad. Sci. USA 93: 2879-2883 (1996). cited by other .
Klinman et al., "CpG Motifs as Immune Adjuvants," Vaccine 17: 19-25 (1999). cited by other .
Krieg et al., "CpG Motifs in Bacterial DNA Trigger Direct B-Cell Activation," Nature 374: 546-549 (1995). cited by other .
Liang et al., "Activation of Human B Cells by Phosphorothioate Oligodeoxynucleotides," J. Clin. Invest. 98: 1119-1129 (1996). cited by other .
Lonnberg et al., "Towards Genomic Drug Therapy with Antisense Oligonucleotides," Ann. Med. 28: 511-522 (1996). cited by other .
McCluskie et al., "CpG DNA is a Potent Enhancer of Systemic & Mucosal Immune Response Against Hepatitis B Surface Antigen with Intra-Nasal Administration to Mice," J. Immun. 161: 4463-4465 (1998). cited by other .
Oberbauer, "Not Non-Sense but Antisense-Applications of Antisense Oligonucleotides in Different Fields of Medicine," Wein Klin Wochenschr 109: 40-46 (1997). cited by other .
Scanlon et al., "Oligonucleotide-Mediated Modulation of Mammalian Gene Expression," FASEB J. 9: 1288-1295 (1995).. cited by other .
Yi et al., "Rapid Immune Activation by CpG Motifs in Bacterial DNA," J. Immun. 157: 5394-5402 (1996). cited by other .
Adya, et al., "Expansion of CREB's DNA recognition specificity by Tax results from interaction with Ala-Ala-Arg at positions 282-284 near the conserved DNA-binding domain of CREB". Proc. Natl. Acad. Sci. USA 91(12):5642-5646 (1994). cited by other .
Agrawal, et al., "Pharmacokinetics of Oligonucleotides". Ciba. Found. Symp. 209:60-78 (1997), abstract. cited by other .
Agrawal, et al., "Pharmacokinetics and Bioavailability of Antisense Oligonucleotides Following Oral and Colorectal Adminstration of Experimental Animals". Handb. Exp. Pharmacol.: Antisense Research and Application 131:525-543 (1998). cited by other .
Agrawal, "Antisense Oligonucleotides: Toward Clinical Trials". Tibtech 14:376-387 (1996). cited by other .
Agrawal, et al., "In Vivo Pharmacokinetics of Phosphorothioate Oligonucleotides Containing Contiguous Guanosines". Antisense & Nucleic Acid Drug Development 7:245-249 (1997). cited by other .
Agrawal, et al., "Absorption, Tissue Distribution and In Vivo Stability in Rats of a Hybrid Antisense Oligonucleotide Following Oral Administration". Biochemical Pharmacology 50(4):571-576 (1995). cited by other .
Agrawal, et al., "Pharmacokinetics of Antisense Oligonucleotides". Clin. Pharmacokinet 28(1):7 (1995). cited by other .
Agrawal, et al., "Antisense therapeutics: is it as simple as complementary base recognition?". Molecular Med. Today 6(2):72-81 (2000), abstract. cited by other .
Agrawal, et al., "Pharmacokinetics, biodistribution, and stability of oligodeoxynucleotide phosphorothioates in mice". Proc. Natl. Acad. Sci. USA 88:7595-7599 (1991). cited by other .
Agrawal, "Medicinal Chemistry and Therapeutic Potential of CpG DNA". Trends in Molecular Medicine 8(3):114-121 (2002). cited by other .
Amaral, et al., "Leishmania amazonensis: The asian rhesus macaques (Macaca mulatta) as an experimental model for study of Cutaneous leishmaniasis". Exp. Parasitol. 82(1):34-44 (1996). cited by other .
Anderson, "Human Gene Therapy". Nature 392:25-30 (Apr. 1998). cited by other .
Anderson, et al., "TH2 and `TH2-like` cells in allergy and asthma; pharmacological perspectives". TiPS 15:324-332 (1994). cited by other .
Anfossi, et al., "An oligomer complementary to c-myb-encoded mRNA inhibits proliferation of human myeloid leukemia cell lines". Proc. Natl. Acad. Sci. USA 86:3379-3383 (May 1989). cited by other .
Angier, "Microbe DNA seen as alien by immune system". New York Times p. C1, 2 pages (1995). cited by other .
Azad, et al., "Antiviral activity of a phosphorothioate oligonucleotide complementary to RNA of the human cytomegalovirus major immediate-early region". Amtimicrobial Agents and Chemotherapy 37:1945-1954 (1993). cited by other .
Azuma, "Biochemical and immunological studies on cellular components of tubercle bacilli". Kekkaku 69(9):

Free Web Sudoku Puzzles.
Solve with your browser.
    5   9   7    
        1        
      2   3   4 8
9   2 8         7
  8           6  
6         2 1   3
4 3   1   5      
        8        
    1   7   6    
What is it?



Add Your Site · Terms Of Service · Privacy Policy


DISCLAIMER
Linkgrinder is a free service that searches the Internet and indexes all files found so that you may search quickly and easily for shared files. These files are created and made available individually by users whose identity we are not aware of and who we have no control over. In essence we function like a search engine tool; these files ARE NOT STORED OR SERVED BY OUR NETWORK. We are not responsible for any materials obtained by using our service. We do not monitor any of the contents of these files. These files may contain viruses, illegal materials, materials inappropriate for minors, offensive files and the like. BY USING OUR SERVICE, YOU ASSUME FULL RESPONSIBILITY FOR DOWNLOADING THESE MATERIALS AND WILL INDEMNIFY US FOR ANY DAMAGES THAT MAY BE INCURRED.

For More Specific Information VIEW OUR TERMS OF SERVICE.

Thank you and Enjoy!