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Nitrogen-containing bicyclic heterocycles for use as antibacterials Number:7,141,564 from the United States Patent and Trademark Office (PTO) owispatent

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Title: Nitrogen-containing bicyclic heterocycles for use as antibacterials

Abstract: Cyclohexane and cyclohexene derivatives and pharmaceutically acceptable derivatives thereof useful in methods of treatment of bacterial infections in mammals, particularly man.

Patent Number: 7,141,564 Issued on 11/28/2006 to Brooks,   et al.


Inventors: Brooks; Gerald (Harlow, GB), Davies; David Thomas (Harlow, GB), Jones; Graham Elgin (Harlow, GB), Markwell; Roger Edward (Harlow, GB), Pearson; Neil David (Harlow, GB)
Assignee: SmithKline Beecham p.l.c. (Brentford, GB)
Appl. No.: 10/478,154
Filed: May 24, 2002
PCT Filed: May 24, 2002
PCT No.: PCT/EP02/05708
371(c)(1),(2),(4) Date: April 06, 2004
PCT Pub. No.: WO03/087098
PCT Pub. Date: October 23, 2003


Foreign Application Priority Data

May 25, 2001 [GB] 0112834

Current U.S. Class: 514/224.2 ; 514/230.5; 514/248; 514/259.2; 514/260.1; 514/300; 514/301; 514/502; 544/105; 544/255; 544/282; 544/293; 544/48; 544/51; 544/52; 546/113; 546/114; 546/115; 546/122; 546/159
Current International Class: A61K 31/542 (20060101); A61K 31/4375 (20060101); A61P 31/04 (20060101); C07D 471/04 (20060101); C07D 513/04 (20060101)
Field of Search: 546/115,114,113,122 544/52,51,48,105,255,282 514/224.2,230.5,259.2,260.1,302,301,300,248,502 542/113,114,115,122,159


References Cited [Referenced By]

U.S. Patent Documents
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5849757 December 1998 Takemura et al.
6187797 February 2001 Prvitt et al.
6602882 August 2003 Davies et al.
2003/0229119 December 2003 Kym et al.
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2004/0077656 April 2004 Markwell et al.
2004/0138219 July 2004 Davies et al.
2004/0198755 October 2004 Dartois et al.
2004/0198756 October 2004 Davies et al.
2005/0085494 April 2005 Daines et al.
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Other References

US. Appl. No. 10/518,653; "Compounds"; filed Jun. 25, 2003 in the names of J. Axten, R. Daines, D. Davies, T. Gallagher, G. Jones, W. Miller, N. Pearson, I. Pendrak; Preliminary Amendment mailed Dec. 16, 2004 therein. cited by other.

Primary Examiner: Owens; Amelia A.
Attorney, Agent or Firm: Sauermelch; Loretta J. McCarthy; Mary E. Kinzig; Charles M.

Claims



What is claimed is:

1. A compound of formula (I) or a pharmaceutically acceptable salt, solvate or N-oxide thereof: ##STR00138## wherein: one of Z.sup.1, Z.sup.2, and Z.sup.3 is N, one of the remainder of Z.sub.1, Z.sub.2, Z.sub.3, Z.sub.4 and Z.sub.5 is CR.sup.1a and the remainder are CH; R.sup.v and R.sup.w are hydrogen; R.sup.v and R.sup.3; or R.sup.v and R.sup.w together are a bond; R.sup.1 and R.sup.1a are independently selected from hydrogen; hydroxy; (C.sub.1-6) alkoxy optionally substituted by (C.sub.1-6)alkoxy, amino, piperidyl, guanidino or amidino any of which is optionally N-substituted by one or two (C.sub.1-6)alkyl, (C.sub.1-6)alkoxycarbonyl, formyl, (C.sub.1-6)alkylcarbonyl, or (C.sub.1-6)alkylsulphonyl groups, CONH2, hydroxy, (C.sub.1-6)alkylthio, heterocyclylthio, heterocyclyloxy, arylthio, aryloxy, (C.sub.1-6)alkyloxycarbonylthio, formylthio, (C.sub.1-6)alkylcarbonylthio, (C.sub.1-6)alkyloxycarbonyloxy, formyloxy, (C.sub.1-6)alkylcarbonyloxy or (C.sub.1-6)alkylsulphonyloxy; (C.sub.1-6)alkoxy-substituted (C.sub.1-6)alkyl; halogen; (C.sub.1-6)alkyl; (C.sub.1-6)alkylthio; trifluromethyl; nitro; azido; (C.sub.1-6)alkoxycarbonyl; formyl; (C.sub.1-6)alkylcarbonyl; (C.sub.1-6)alkyloxycarbonyloxy, formyloxy, (C.sub.1-6)alkylcarbonyloxy, (C.sub.1-6)alkyloxycarbonylthio, formylthio; (C.sub.1-6)alkylcarbonylthio; (C.sub.1-6)alkylsulphonyl; (C.sub.1-6)alkylsulphoxide; arylsulphonyl; arylsulphoxide or an amino, piperidyl, guanidino or amidino group optionally N-substituted by one or two (C.sub.1-6)alkyl, (C.sub.1-6)alkoxycarbonyl, formyl, (C.sub.1-6)alkylcarbonyl or (C.sub.1-6)alkylsulphonyl groups, or when Z.sup.1 is CR.sup.1a, R.sup.1 and R.sup.1a may together represent (C.sub.1-2)alkylenedioxy; or when Z.sup.5 is CR.sup.1a, R.sup.1a may instead be cyano, hydroxymethyl or carboxy; R.sup.2 is hydrogen, or (C.sub.1-4)alkyl or (C.sub.2-4)alkenyl optionally substituted with 1 to 3 groups selected from: amino optionally substituted by one or two (C.sub.1-4)alkyl groups; carboxy; (C.sub.1-4)alkoxycarbonyl; (C.sub.1-4)alkylcarbonyl; (C.sub.2-4)alkenyloxycarbonyl; (C.sub.2-4)alkenylcarbonyl; aminocarbonyl wherein the amino group is optionally substituted by hydroxy, (C.sub.1-4)alkyl, hydroxy(C.sub.1-4)alkyl, aminocarbonyl(C.sub.1-4)alkyl, (C.sub.2-4)alkenyl, (C.sub.1-4)alkylsulphonyl, trifluoromethylsulphonyl, (C.sub.2-4)alkenylsulphonyl, (C.sub.1-4)alkoxycarbonyl, (C.sub.1-4)alkylcarbonyl, (C.sub.2-4)alkenyloxycarbonyl or (C.sub.2-4)alkenylcarbonyl; cyano; tetrazolyl; 2-oxo-oxazolidinyl optionally substituted by R.sup.10; 3-hydroxy-3-cyclobutene-1,2-dione-4-yl; 2,4-thiazolidinedione-5-yl; tetrazol-5-ylaminocarbonyl; 1,2,4-triazol-5-yl optionally substituted by R.sup.10; 5-oxo-1,2,4-oxadiazol-3-yl; halogen; (C.sub.1-4)alkylthio; trifluoromethyl; hydroxy optionally substituted by (C.sub.1-4)alkyl, (C.sub.2-4)alkenyl, (C.sub.1-4)alkoxycarbonyl, (C.sub.1-4)alkylcarbonyl, (C.sub.2-4)alkenyloxycarbonyl, (C.sub.2-4)alkenylcarbonyl; oxo; (C.sub.1-4)alkylsulphonyl; (C.sub.2-4)alkenylsulphonyl; or (C.sub.1-4)aminosulphonyl wherein the amino group is optionally substituted by (C.sub.1-4)alkyl or (C.sub.2-4)alkenyl; when R.sup.v and R.sup.w are a bond, R.sup.3 is in the 2-, 3- or 4-position and when R.sup.v and R.sup.w are not a bond, R.sup.3 is in the 1-, 2-, 3- or 4-position and R.sup.3 is: hydrogen; carboxy; (C.sub.1-6)alkoxycarbonyl; aminocarbonyl wherein the amino group is optionally substituted by hydroxy, (C.sub.1-6)alkyl, hydroxy(C.sub.1-6)alkyl, aminocarbonyl(C.sub.1-6)alkyl, (C.sub.2-6)alkenyl, (C.sub.1-6)alkylsulphonyl, trifluoromethylsulphonyl, (C.sub.2-6)alkenylsulphonyl, (C.sub.1-6)alkoxycarbonyl, (C.sub.1-6)alkylcarbonyl, (C.sub.2-6)alkenyloxycarbonyl or (C.sub.2-6)alkenylcarbonyl and optionally further substituted by (C.sub.1-6)alkyl, hydroxy(C.sub.1-6)alkyl, aminocarbonyl(C.sub.1-6)alkyl or (C.sub.2-6)alkenyl; cyano; tetrazolyl; 2-oxo-oxazolidinyl optionally substituted by R.sup.10; 3-hydroxy-3-cyclobutene-1,2-dione-4-yl; 2,4-thiazolidinedione-5-yl; tetrazol-5-ylaminocarbonyl; 1,2,4-triazol-5-yl optionally substituted by R.sup.10; or 5-oxo-1,2,4-oxadiazol-3-yl; or (C.sub.1-4)alkyl or ethenyl optionally substituted with any of the groups listed above for R.sup.3 and/or 0 to 2 groups R.sup.12 independently selected from: halogen; (C.sub.1-6)alkylthio; trifluoromethyl; (C.sub.1-6)alkoxycarbonyl; (C.sub.1-6)alkylcarbonyl; (C.sub.2-6)alkenyloxycarbonyl; (C.sub.2-6)alkenylcarbonyl; hydroxy optionally substituted by (C.sub.1-6)alkyl, (C.sub.2-6)alkenyl, (C.sub.1-6)alkoxycarbonyl, (C.sub.1-6)alkylcarbonyl, (C.sub.2-6)alkenyloxycarbonyl, (C.sub.2-6)alkenylcarbonyl or aminocarbonyl wherein the amino group is optionally substituted by (C.sub.1-6)alkyl, (C.sub.2-6)alkenyl, (C.sub.1-6)alkylcarbonyl or (C.sub.2-6)alkenylcarbonyl; amino optionally mono- or disubstituted by (C.sub.1-6)alkoxycarbonyl, (C.sub.1-6)alkylcarbonyl, (C.sub.2-6)alkenyloxycarbonyl, (C.sub.2-6)alkenylcarbonyl, (C.sub.1-6)alkyl, (C.sub.2-6)alkenyl, (C.sub.1-6)alkylsulphonyl, (C.sub.2-6)alkenylsulphonyl or aminocarbonyl wherein the amino group is optionally substituted by (C.sub.1-6)alkyl or (C.sub.2-6)alkenyl; aminocarbonyl wherein the amino group is optionally substituted by (C.sub.1-6)alkyl, hydroxy(C.sub.1-6)alkyl, aminocarbonyl(C.sub.1-6)alkyl, (C.sub.2-6)alkenyl, (C.sub.1-6)alkoxycarbonyl, (C.sub.1-6)alkylcarbonyl, (C.sub.2-6)alkenyloxycarbonyl or (C.sub.2-6)alkenylcarbonyl and optionally further substituted by (C.sub.1-6)alkyl, hydroxy(C.sub.1-6)alkyl, aminocarbonyl(C.sub.1-6)alkyl or (C.sub.2-6)alkenyl; oxo; (C.sub.1-6)alkylsulphonyl; (C.sub.2-6)alkenylsulphonyl; or (C.sub.1-6)aminosulphonyl wherein the amino group is optionally substituted by (C.sub.1-6)alkyl or (C.sub.2-6)alkenyl; or hydroxy optionally substituted by (C.sub.1-6)alkyl, (C.sub.2-6)alkenyl, (C.sub.1-6)alkoxycarbonyl, (C.sub.1-6)alkylcarbonyl, (C.sub.2-6)alkenyloxycarbonyl, (C.sub.2-6)alkenylcarbonyl or aminocarbonyl wherein the amino group is optionally substituted by (C.sub.1-6)alkyl, (C.sub.2-6)alkenyl, (C.sub.1-6)alkylcarbonyl or (C.sub.2-6)alkenylcarbonyl; or amino optionally mono- or disubstituted by (C.sub.1-6)alkoxycarbonyl, (C.sub.1-6)alkylcarbonyl, (C.sub.2-6)alkenyloxycarbonyl, (C.sub.2-6)alkenylcarbonyl, (C.sub.1-6)alkyl, (C.sub.2-6)alkenyl, (C.sub.1-6)alkylsulphonyl, (C.sub.2-6)alkenylsulphonyl or aminocarbonyl wherein the amino group is optionally substituted by (C.sub.1-6)alkyl or (C.sub.2-6)alkenyl; provided that when R.sup.3 is in the 4-position it is not optionally substituted hydroxyl or amino; in addition when R.sup.3 is disubstituted with a hydroxy or amino containing substituent and a carboxy containing substituent these may optionally together form a cyclic ester or amide linkage, respectively; R.sup.10 is selected from (C.sub.1-4)alkyl and (C.sub.2-4)alkenyl either of which may be optionally substituted by a group R.sup.12 as defined above; carboxy; aminocarbonyl wherein the amino group is optionally substituted by hydroxy, (C.sub.1-6)alkyl, (C.sub.2-6)alkenyl, (C.sub.1-6)alkylsulphonyl, trifluoromethylsulphonyl, (C.sub.2-6)alkenylsulphonyl, (C.sub.1-6)alkoxycarbonyl, (C.sub.1-6)alkylcarbonyl, (C.sub.2-6)alkenyloxycarbonyl or (C.sub.2-6)alkenylcarbonyl and optionally further substituted by (C.sub.1-6)alkyl or (C.sub.2-6)alkenyl; (C.sub.1-6)alkylsulphonyl; trifluoromethylsulphonyl; (C.sub.2-6)alkenylsulphonyl; (C.sub.1-6)alkoxycarbonyl; (C.sub.1-6)alkylcarbonyl; (C.sub.2-6)alkenyloxycarbonyl; and (C.sub.2-6)alkenylcarbonyl; R.sup.4 is a group --CH.sub.2--R.sup.5.sub.1 in which R.sup.5.sub.1 is selected from: (C.sub.4-8)alkyl; hydroxy(C.sub.4-8)alkyl; (C.sub.1-4)alkoxy(C.sub.4-8)alkyl; (C.sub.1-4)alkanoyloxy(C.sub.4-8)alkyl; (C.sub.3-8)cycloalkyl(C.sub.4-8)alkyl; hydroxy-, (C.sub.1-6)alkoxy- or (C.sub.1-6)alkanoyloxy-(C.sub.3-8)cycloalkyl(C.sub.4-8)alkyl; cyano(C.sub.4-8)alkyl; (C.sub.4-8)alkenyl; (C.sub.4-8)alkynyl; tetrahydrofuryl; mono- or di-(C.sub.1-6)alkylamino(C.sub.4-8)alkyl; acylamino(C.sub.4-8)alkyl; (C.sub.1-6)alkyl- or acyl-aminocarbonyl(C.sub.4-8)alkyl; mono- or di-(C.sub.1-6)alkylamino(hydroxy) (C.sub.4-8)alkyl; or R.sup.4 is a group --U--R.sup.5.sub.2 where R.sup.5.sub.2 is an optionally substituted bicyclic carbocyclic or heterocyclic ring system (A): ##STR00139## containing up to four heteroatoms in each ring in which at least one of rings (a) and (b) is aromatic; X.sup.1 is C or N when part of an aromatic ring or CR.sup.14 when part of a non aromatic ring; X.sup.2 is N, NR.sup.13, O, S(O).sub.x, CO or CR.sup.14 when part of an aromatic or non-aromatic ring or may in addition be CR.sup.14R.sup.15 when part of a non aromatic ring; X.sup.3 and X.sup.5 are independently N or C; Y.sup.1 is a 0 to 4 atom linker group each atom of which is independently selected from N, NR.sup.13, O, S(O).sub.x, CO and CR.sup.14 when part of an aromatic or non-aromatic ring or may additionally be CR.sup.14R.sup.15 when part of a non aromatic ring, Y.sup.2 is a 2 to 6 atom linker group, each atom of Y.sup.2 being independently selected from N, NR.sup.13, O, S(O).sub.x, CO and CR.sup.14 when part of an aromatic or non-aromatic ring or may additionally be CR.sup.14R.sup.15 when part of a non aromatic ring; each of R.sup.14 and R.sup.15 is independently selected from: H; (C.sub.1-4)alkylthio; halo; carboxy(C.sub.1-4)alkyl; halo(C.sub.1-4)alkoxy, halo(C.sub.1-4)alkyl; (C.sub.1-4)alkyl; (C.sub.2-4)alkenyl; (C.sub.1-4)alkoxycarbonyl; formyl; (C.sub.1-4)alkylcarbonyl; (C.sub.2-4)alkenyloxycarbonyl; (C.sub.2-4)alkenylcarbonyl; (C.sub.1-4)alkylcarbonyloxy; (C.sub.1-4)alkoxycarbonyl(C.sub.1-4)alkyl; hydroxy; hydroxy(C.sub.1-4)alkyl; mercapto(C.sub.1-4)alkyl; (C.sub.1-4)alkoxy; nitro; cyano; carboxy; amino or aminocarbonyl optionally substituted as for corresponding substituents in R.sup.3; (C.sub.1-4)alkylsulphonyl; (C.sub.2-4)alkenylsulphonyl; or aminosulphonyl wherein the amino group is optionally substituted by (C.sub.1-4)alkyl or (C.sub.2-4)alkenyl; aryl; aryl(C.sub.1-4)alkyl; aryl(C.sub.1-4)alkoxy; each R.sup.13 is independently H; trifluoromethyl; (C.sub.1-4)alkyl optionally substituted by hydroxy, carboxy, (C.sub.1-6)alkoxycarbonyl, (C.sub.1-6)alkoxy, (C.sub.1-6)alkylthio, halo or trifluoromethyl; (C.sub.2-4)alkenyl; aryl; aryl (C.sub.1-4)alkyl; arylcarbonyl; heteroarylcarbonyl; (C.sub.1-4)alkoxycarbonyl; (C.sub.1-4)alkylcarbonyl; formyl; (C.sub.1-6)alkylsulphonyl; or aminocarbonyl wherein the amino group is optionally substituted by (C.sub.1-4)alkoxycarbonyl, (C.sub.1-4)alkylcarbonyl, (C.sub.2-4)alkenyloxycarbonyl, (C.sub.2-4)alkenylcarbonyl, (C.sub.1-4)alkyl or (C.sub.2-4)alkenyl and optionally further substituted by (C.sub.1-4)alkyl or (C.sub.2-4)alkenyl; each x is independently 0, 1 or 2; U is CO, SO.sub.2 or CH.sub.2; or R.sup.4 is a group --X.sup.1a--X.sup.2a--X.sup.3a--X.sup.4a in which: X.sup.1a is CH.sub.2, CO or SO.sub.2; X.sup.2a is CR.sup.14aR.sup.15a; X.sup.3a is NR.sup.13a, O, S, SO.sub.2 or CR.sup.14aR.sup.15a; wherein: each of R.sup.14a and R.sup.15a is independently selected from the groups listed above for R.sup.14 and R.sup.15, provided that R.sup.14a and R.sup.15a on the same carbon atom are not both selected from optionally substituted hydroxy and optionally substituted amino; or R.sup.14a and R.sup.15a together represent oxo; R.sup.13a is hydrogen; trifluoromethyl; (C.sub.1-6)alkyl; (C.sub.2-6)alkenyl; (C.sub.1-6)alkoxycarbonyl; (C.sub.1-6)alkylcarbonyl; or aminocarbonyl wherein the amino group is optionally substituted by (C.sub.1-6)alkoxycarbonyl, (C.sub.1-6)alkylcarbonyl, (C.sub.2-6)alkenyloxycarbonyl, (C.sub.2-6)alkenylcarbonyl, (C.sub.1-6)alkyl or (C.sub.2-6)alkenyl and optionally further substituted by (C.sub.1-6)alkyl or (C.sub.2-6)alkenyl; or two R.sup.14a groups or an R.sup.13a and an R.sup.14a group on adjacent atoms together represent a bond and the remaining R.sup.13a, R.sup.14a and R.sup.15a groups are as above defined; or two R.sup.14a groups and two R.sup.15a groups on adjacent atoms together represent bonds such that X.sup.2a and X.sup.3a is triple bonded; X.sup.4a is phenyl or C or N linked monocyclic aromatic 5- or 6-membered heterocycle containing up to four heteroatoms selected from O, S and N and: optionally C-substituted by up to three groups selected from (C.sub.1-4)alkylthio; halo; carboxy(C.sub.1-4)alkyl; halo(C.sub.1-4)alkoxy; halo(C.sub.1-4)alkyl; (C.sub.1-4)alkyl; (C.sub.2-4)alkenyl; (C.sub.1-4)alkoxycarbonyl; formyl; (C.sub.1-4)alkylcarbonyl; (C.sub.2-4)alkenyloxycarbonyl; (C.sub.2-4)alkenylcarbonyl; (C.sub.1-4)alkylcarbonyloxy; (C.sub.1-4)alkoxycarbonyl(C.sub.1-4)alkyl; hydroxy; hydroxy(C.sub.1-4)alkyl; mercapto(C.sub.1-4)alkyl; (C.sub.1-4)alkoxy, nitro; cyano; carboxy; amino or aminocarbonyl optionally substituted as for corresponding substituents in R.sup.3; (C.sub.1-4)alkylsulphonyl; (C.sub.2-4)alkenylsulphonyl; or aminosulphonyl wherein the amino group is optionally substituted by (C.sub.1-4)alkyl or (C.sub.2-4)alkenyl; aryl, aryl(C.sub.1-4)alkyl or aryl(C.sub.1-4)alkoxy; and optionally N substituted by trifluoromethyl; (C.sub.1-4)alkyl optionally substituted by hydroxy, (C.sub.1-6)alkoxy, (C.sub.1-6)alkylthio, halo or trifluoromethyl; (C.sub.2-4)alkenyl; aryl; aryl(C.sub.1-4)alkyl; (C.sub.1-4)alkoxycarbonyl; (C.sub.1-4)alkylcarbonyl; formyl; (C.sub.1-6)alkylsulphonyl; or aminocarbonyl wherein the amino group is optionally substituted by (C.sub.1-4)alkoxycarbonyl, (C.sub.1-4)alkylcarbonyl, (C.sub.2-4)alkenyloxycarbonyl, (C.sub.2-4)alkenylcarbonyl, (C.sub.1-4)alkyl or (C.sub.2-4)alkenyl and optionally further substituted by (C.sub.1-4)alkyl or (C.sub.2-4)alkenyl; n is 0 or 1 and AB is NR.sup.11CO, CONR.sup.11, CO--CR.sup.8R.sup.9, CR.sup.6R.sup.7-CO, O--CR.sup.8R.sup.9, CR.sup.6R.sup.7-O, NR.sup.11--CR.sup.8R.sup.9, CR.sup.6R.sup.7--NR.sup.11, NR.sup.11SO.sub.2, CR.sup.6R.sup.7--SO.sub.2 or CR.sup.6R.sup.7--CR.sup.8R.sup.9, provided that when R.sup.v and R.sup.w are a bond and n=0, B is not NR.sup.11, O or SO.sub.2, or n is 0 and AB is NH--CO--NH or NH--CO--O and R.sup.v/R.sup.w are not a bond; or n is 0 and AB is CR.sup.6R.sup.7SO.sub.2NR.sup.2, CR.sup.6R.sup.7CONR.sup.2 or CR.sup.6R.sup.7CH.sub.2NR.sup.2 and R.sup.v/R.sup.w are not a bond; provided that R.sup.6 and R.sup.7, and R.sup.8 and R.sup.9 are not both optionally substituted hydroxy or amino; and wherein: each of R.sup.6, R.sup.7, R.sup.8 and R.sup.9 is independently selected from: H; (C.sub.1-6)alkoxy; (C.sub.1-6)alkylthio; halo; trifluoromethyl; azido; (C.sub.1-6)alkyl; (C.sub.2-6)alkenyl; (C.sub.1-6)alkoxycarbonyl; (C.sub.1-6)alkylcarbonyl; (C.sub.2-6)alkenyloxycarbonyl; (C.sub.2-6)alkenylcarbonyl; hydroxy, amino or aminocarbonyl optionally substituted as for corresponding substituents in R.sup.3; (C.sub.1-6)alkylsulphonyl; (C.sub.2-6)alkenylsulphonyl; or (C.sub.1-6)aminosulphonyl wherein the amino group is optionally substituted by (C.sub.1-6)alkyl or (C.sub.2-6)alkenyl; or R.sup.6 and R.sup.8 together represent a bond and R.sup.7 and R.sup.9 are as above defined; and each R.sup.11 is independently H; trifluoromethyl; (C.sub.1-6)alkyl; (C.sub.2-6)alkenyl; (C.sub.1-6)alkoxycarbonyl; (C.sub.1-6)alkylcarbonyl; or aminocarbonyl wherein the amino group is optionally substituted by (C.sub.1-6)alkoxycarbonyl, (C.sub.1-6)alkylcarbonyl, (C.sub.2-6)alkenyloxycarbonyl, (C.sub.2-6)alkenylcarbonyl, (C.sub.1-6)alkyl or (C.sub.2-6)alkenyl and optionally further substituted by (C.sub.1-6)alkyl or (C.sub.2-6)alkenyl.

2. A compound according to claim 1 wherein Z.sup.1 is N, Z.sup.3 is CH or CF and Z.sup.2, Z.sup.4 and Z.sup.5 are each CH.

3. A compound according to claim 1 wherein R.sup.1 is methoxy or fluoro and R.sup.1a is H or when Z.sup.3 is CR.sup.1a it may be C--F.

4. A compound according to claim 1 wherein R.sup.2 is hydrogen.

5. A compound according to claim 1 wherein R.sup.3 is hydrogen or hydroxy substituted in the 1-or 3-position.

6. A compound according to claim 1 wherein n is 0 and either A is CHOH or CH.sub.2 and B is CH.sub.2 or A is NH and B is CO, and AB(CH.sub.2).sub.n and NR.sup.2R.sup.4 are trans.

7. A compound according to claim 1 wherein R.sup.4 is --U--R.sup.5.sub.2, the group --U-- is --CH.sub.2--, and R.sup.5.sub.2 is an aromatic heterocyclic ring (A) having 8-11 ring atoms including 2-4 heteroatoms of which at least one is N or NR.sup.13 in which Y.sup.2 contains 2-3 heteroatoms, one of which is S and 1-2 are N, with one N bonded to X.sup.3, or the heterocyclic ring (A) has ring (a) aromatic selected from optionally substituted benzo and pyrido and ring (b) non-aromatic and Y.sup.2 has 3-5 atoms including heteroatom bonded to X.sup.5 selected from NR.sup.13, O or S, where R13 is other than hydrogen, and NHCO bonded via N to X.sup.3, or O bonded to X.sup.3.

8. A compound according to claim 1 wherein R.sup.5.sub.2 is selected from: benzo[1,2,5]thiadiazol-5-yl 3-oxo-3,4-dihydro-2H-benzo[1,4]thiazin-6-yl (4H-benzo[1,4]thiazin-3-one-6-yl) 2,3-dihydro-benzo[1,4]dioxin-6-yl benzo[1,2,3]thiadiazol-5-yl 3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl 7-fluoro-3-oxo-3,4-dihydro-2H-benzo[1,4] oxazin-6-yl 2-oxo-2,3-dihydro-1H-pyrido[2,3-b]thiazin-7-yl 2,3-Dihydro-[1,4]dioxino[2,3-c]pyridin-7-yl 3-oxo-3,4-dihydro-2H-pyrido[2,3-b]oxazin-6-yl [1,2,3]thiadiazolo[5,4-b]pyridin-6-yl.

9. A compound according to claim 1, selected from: Trans-4-[(8-Hydroxy-quinolin-2-ylmethyl)-amino]-cyclohexanecarboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; Trans-4-[(Benzo[1,2,5]thiadiazol-5-ylmethyl)-amino]-cyclohexanecarboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; Trans-4-[(1H-Pyrrolo[2,3-b]pyridin-2-ylmethyl)-amino]-cyclohexanecarboxyl- ic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; Trans-4-[(3-Oxo-3,4-dihydro-2H-benzo[1,4]thiazin-6-ylmethyl)-amino]-cyclo- hexane carboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; Trans-4-[(2,3-Dihydro-benzo[1,4]dioxin-6-ylmethyl)-amino]-cyclohexanecarb- oxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; Trans-4-[(Benzo[1,2,3]thiadiazol-5-yl-ylmethyl)-amino]-cyclohexanecarboxy- lic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; Trans-4-[(3-Methyl-2-oxo-2,3-dihydro-benzooxazol-6-ylmethyl)-amino]-cyclo- hexanecarboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; Trans-4-[(3-Oxo-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethyl)-amino]-cycloh- exanecarboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; Trans-4-[(7-Fluoro-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethyl)-amin- o]-cyclohexanecarboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; Trans-4-[(2-Oxo-2,3-dihydro-1H-pyrido[2,3-b][1,4]thiazin-7-ylmethyl)-amin- o]-cyclohexanecarboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; Trans-4-[(3,4-Dihydro-2H-benzo[1,4]oxazin-6-ylmethyl)-amino]-cyclohexanec- arboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; Trans-4-[(Thiazolo[5,4-b]-pyridin-6-ylmethyl)-amino]-cyclohexanecarboxyli- c acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; Trans-4-[(8-Hydroxy-1-oxo-1,2-dihydro-isoquinolin-3-ylmethyl)-amino]-cycl- ohexanecarboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; Trans-4-[(2,3-Dihydro-[1,4]dioxino[2,3-b]pyridin-6-ylmethyl)-amino]-cyclo- hexanecarboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; Trans-4-[(2,3-Dihydro-[1,4]dioxino[2,3-c]pyridin-7-ylmethyl)-amino]-cyclo- hexanecarboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; Trans-4-[(2,3-Dihydro-[1,4]dioxino[2,3-b]pyridin-7-ylmethyl)-amino]-cyclo- hexanecarboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; Trans-4-[(6-Nitro-benzo[1,3]dioxol-5-ylmethyl)-amino]-cyclohexanecarboxyl- ic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; Trans-4-[(6-Amino-benzo[1,3]dioxol-5-ylmenthyl)-amino]-cyclohexanecarboxy- lic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; Trans-4-[(Benzothiazol-5-ylmethyl)-amino]cyclohexanecarboxylic acid(6-methoxy-[1,5]naphthyridine-4-yl)amide; Trans-4-[(4-Oxo-4 H pyrido[1,2-a]pyrimidin-2-ylmethyl)-amino]-cyclohexanecarboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; Trans-4-[(2,3-Dihydro-benzo[1,4]dioxin-6-ylmethyl)-amino]-cyclohexanecarb- oxylic acid [6-(3-amino-propoxy)-[1,5]naphthyridin-4-yl]-amide; Trans-4-[(3-Oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-6-ylmethyl)-amino- ]-cyclohexanecarboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; Trans-4-[([1,2,3]Thiadiazolo[5,4-b]pyridin-6-ylmethyl)-amino]-cyclohexane- carboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; Trans-4-(3-Oxo-3,4-dihydro-2H-benzo[1,4]thiazine-6-sulfonylamino)-cyclohe- xanecarboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; Trans-4-[(7-Fluoro-3-oxo-3,4-dihydro-2H-benzo[1,4]thiazin-6-ylmethyl)-ami- no]-cyclohexanecarboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; Trans-4-[(8-Nitro-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethyl)-amino- ]-cyclohexanecarboxylic acid (6-methoxy)-[1,5]naphthyridin-4-yl)-amide; Trans-4-[(8-Amino-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethyl)-amino- ]-cyclohexanecarboxylic acid (6-methoxy)-[1,5]naphthyridin-4-yl)-amide; (R/S)-4-[(3-Oxo-3,4-dihydro-2H-benzo[1,4]thiazin-6-ylmethyl)-amino]-cyclo- hex-1-ene carboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; (R/S)-4-[(Benzo[1,2,5]thiadiazol-5-ylmethyl)-amino]-cyclohexene carboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; (R/S)-4-[(Benzo[1,2,3]thiadiazol-5-ylmethyl)-amino]-cyclohex-1-ene carboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)amide; (R/S)-4-[(2-Oxo-2,3-dihydro-1H-pyrido[2,3-b][1,4]thiazin-7-ylmethyl)-amin- o]-cyclohex-1-ene carboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; (R/S)-4-[(7-Fluoro-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethyl)-amin- o]-cyclohex-1-ene carboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; (R/S)-4-[(2-Oxo-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-ylmethyl)-amino- ]-cyclohex-1-enecarboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; (R/S)-4-[Carboxymethyl-(3-oxo-3,4-dihydro-2H-benzo[1,4]thiazin-6-ylmethyl- )-amino]-cyclohex-1-enecarboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; 1-Hydroxy-t-4-[(3-oxo-3,4-dihydro-2H-benzo[1,4]thiazin-6-ylmethyl)-amino]- -r-cyclohexanecarboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; 1-Hydroxy-t-4-[(3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazin-6-ylmethyl- )-amino]-r-cyclohexanecarboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; 1-Hydroxy-t-4-[(2-oxo-2,3-dihydro-1H-pyrido[3,4-b][1,4]thiazin-7-ylmethyl- )-amino]-r-cyclohexanecarboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; 1-Hydroxy-t-4-[(2-oxo-2,3-dihydro-1H-pyrido[2,3-b][1,4]thiazin-7-ylmethyl- )-amino]-r-cyclohexanecarboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; 1-Hydroxy-t-4-[(7-bromo-3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazin-6-- ylmethyl)-amino]-r-cyclohexanecarboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; 1-Hydroxy-t-4-[(3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-6-ylmethyl)- -amino]-r-cyclohexanecarboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; 1-Hydroxy-t-4-[(7-chloro-3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazin-6- -ylmethyl)-amino]-r-cyclohexanecarboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; 1-Hydroxy-t-4-[(7-oxo-5,6,7,8-tetrahydro-[1,8]naphthyridine-2-ylmethyl)-a- mino]-r-cyclohexanecarboxylic acid (6-methoxy-[1,5]naphthyridine-4-yl)-amide; 1-Hydroxy-t-4-[(7-fluoro-3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazin-6- -ylmethyl)-amino]-r-cyclohexanecarboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; 1-Hydroxy-t-4-[(2-oxo-2,3-dihydro-1H-pyrido[3,4-b][1,4]oxazin-7-ylmethyl)- -amino]-r-cyclohexanecarboxylic acid (6-methyl-[1,5]naphthyridin-4-yl)-amide; 1-Hydroxy-t-4-[(7-methyl-3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazin-6- -ylmethyl)-amino]-r-cyclohexanecarboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; 1-Hydroxy-t-4-[(7-ethyl-3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazin-6-- ylmethyl)-amino]-r-cyclohexanecarboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; 1-Hydroxy-t-4-[(6-oxo-6,7-dihydro-5H-pyridazino[3,4-b][1,4]thiazin-3-ylme- thyl)-amino]-r-cyclohexanecarboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; 1-Hydroxy-t-4-[(3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazin-6-ylmethyl- )-amino]-r-cyclohexanecarboxylic acid [6-(2-methoxy-ethoxy)-[1,5]naphthyridin-4-yl]-amide; (1S,3S,4S)-3-Hydroxy-4-[(3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazin-6- -ylmethyl)-amino]-cyclohexanecarboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide and (1R,3R,4R)-3-Hydroxy-4-[(3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazin-6- -ylmethyl)-amino]-cyclohexanecarboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; (1R,3R,4R)-3-Hydroxy-4-[(3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazin-6- -ylmethyl)-amino]-cyclohexanecarboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; (1S,3S,4S)-3-Hydroxy-4-[(3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1.4]thiazin-6- -ylmethyl)-amino]-cyclohexanecarboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; (1S,3S,4S)-4-[(7-Chloro-3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazin-6-- ylmethyl)-amino]-3-hydroxy-cyclohexanecarboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide and (1R,3R,4R)-4-[(7-chloro-3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazin-6-- ylmethyl)-amino]-3-hydroxy-cyclohexanecarboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; (1S,3S,4S)-3-Hydroxy-4-[(7-fluoro-3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]- thiazin-6-ylmethyl)-amino]-cyclohexanecarboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide and (1R,3R,4R)-3-Hydroxy-4-[(7-fluoro-3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]- thiazin-6-ylmethyl)-amino]-cyclohexanecarboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; (1S,3S,4S)-3-Hydroxy-4-[(2-oxo-2,3-dihydro-1H-pyrido[3,4-b][1,4]oxazin-7-- ylmethyl)-amino]-cyclohexanecarboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide and (1R,3R,4R)-3-Hydroxy-4-[(2-oxo-2,3-dihydro-1H-pyrido[3,4-b][1,4]oxazin-7-- ylmethyl)-amino]-cyclohexanecarboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; (1S,3S,4S)-3-Hydroxy-4-[(2-oxo-2,3-dihydro-1H-pyrido[3,4-b][1,4]thiazin-7- -ylmethyl)-amino]-cyclohexanecarboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide and (1R,3R,4R)-3-Hydroxy-4-[(2-oxo-2,3-dihydro-1H-pyrido[3,4-b][1,4]thiazin-7- -ylmethyl)-amino]-cyclohexanecarboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; (1S,3S,4S)-3-Hydroxy-4-[(6-oxo-6,7-dihydro-5H-8-thia-1,2,5-triaza-naphtha- len-3-ylmethyl)-amino]-cyclohexanecarboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide and (1R,3R,4R)-3-hydroxy-4-[6-oxo-6,7-dihydro-5H-8-thia-1,2,5-triaza-naphthal- en-3-ylmethyl)-amino]-cyclohexanecarboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; (1R,3R,4R)-3-Hydroxy-4-[(3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-6-- ylmethyl)-amino]-cyclohexanecarboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; (1R,3R,4R)-3-Hydroxy-4-[(7-methyl-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazi- n-6-ylmethyl)-amino]-cyclohexanecarboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; (1R,3R,4R)-3-Hydroxy-4-[(2-oxo-2,3-dihydro-1H-pyrido[3,4-b][1,4]thiazin-7- -ylmethyl)-amino]-cyclohexanecarboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; (1S,3S,4S)-3-Hydroxy-4-[(7-methyl-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazi- n-6-ylmethyl)-amino]-cyclohexanecarboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; (1S,3S,4S)-3-Hydroxy-4-[(2-oxo-2,3-dihydro-1H-pyrido[3,4-b][1,4]thiazin-7- -ylmethyl)-amino]-cyclohexanecarboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide; 1-Hydroxy-t-4-[(2,3-dihydro-[1,4]dioxino[2,3-c]pyridin-7-ylmethyl)-amino]- -r-cyclohexanecarboxylic acid (6-methoxy-[1,5]napthyridin-4-yl)-amide; 6-({4-hydroxy-4-[2-(6-methoxy-[1,5]naphthyridin-4-yl)-ethyl]-cyclohexylam- ino}-methyl)-4H-pyrido[3,2-b][1,4]oxazin-3-one; or a pharmaceutically acceptable salt, solvate or N-oxide thereof.

10. A method of treatment of bacterial infections in mammals, which method comprises the administration to a mammal in need of such treatment an effective amount of a compound according to claim 1.

11. A pharmaceutical composition comprising a compound according to claim 1, and a pharmaceutically acceptable carrier.

12. A compound of formula (VI): ##STR00140## wherein one of Z.sup.1, Z.sup.2, or Z.sup.3 is N, and one of the remainder of Z.sub.1, Z.sub.2, Z.sub.3, Z.sub.4, and Z.sub.5 is CR.sup.1a and the remainder are CH; R.sup.v and R.sup.w are hydrogen; R.sup.v and R.sup.3; or R.sup.v and R.sup.w together are a bond; R.sup.1 and R.sup.1a are independently selected from hydrogen; hydroxy; (C.sub.1-6) alkoxy optionally substituted by (C.sub.1-6)alkoxy, amino, piperidyl, guanidino or amidino any of which is optionally N-substituted by one or two (C.sub.1-6)alkyl, (C.sub.1-6)alkoxycarbonyl, formyl, (C.sub.1-6)alkoxycarbonyl, or (C.sub.1-6)alkylsulphonyl groups, CONH2, hydroxy, (C.sub.1-6)alkylthio, heterocyclylthio, heterocyclyloxy, arylthio, aryloxy, (C.sub.1-6)alkyloxycarbonylthio, formylthio, (C.sub.1-6)alkylcarbonylthio; (C.sub.1-6)alkyloxycarbonyloxy; formyloxy, (C.sub.1-6)alkylcarbonyloxy or (C.sub.1-6)alkylsulphonyloxy; (C.sub.1-6)alkoxy-substituted (C.sub.1-6)alkyl; halogen; (C.sub.1-6)alkyl; (C.sub.1-6)alkylthio; trifluromethyl; nitro; azido; (C.sub.1-6)alkoxycarbonyl; formyl; (C.sub.1-6)alkylcarbonyl; (C.sub.1-6)alkyloxycarbonyloxy; formyloxy; (C.sub.1-6)alkylcarbonyloxy; (C.sub.1-6)alkyloxycarbonylthio; formylthio; (C.sub.1-6)alkylcarbonylthio; (C.sub.1-6)alkylsulphonyl; (C.sub.1-6)alkylsulphoxide; arylsulphonyl; arylsulphoxide or an amino, piperidyl, guanidino or amidino group optionally N-substituted by one or two (C.sub.1-6)alkyl, (C.sub.1-6)alkoxycarbonyl, formyl, (C.sub.1-6)alkylcarbonyl or (C.sub.1-6)alkylsulphonyl groups, or when Z.sup.1 is CR.sup.1a, R.sup.1 and R.sup.1a may together represent (C.sub.1-2)alkylenedioxy; or when Z.sup.5 is CR.sup.1a, R.sup.1a may be cyano, hydroxymethyl or carboxy; R.sup.2 is hydrogen, or (C.sub.1-4)alkyl or (C.sub.2-4)alkenyl optionally substituted with 1 to 3 groups selected from: amino optionally substituted by one or two (C.sub.1-4)alkyl groups; carboxy; (C.sub.1-4)alkoxycarbonyl; (C.sub.1-4)alkylcarbonyl; (C.sub.2-4)alkenyloxycarbonyl; (C.sub.2-4)alkenylcarbonyl; aminocarbonyl wherein the amino group is optionally substituted by hydroxy, (C.sub.1-4)alkyl, hydroxy(C.sub.1-4)alkyl, aminocarbonyl(C.sub.1-4)alkyl, (C.sub.2-4)alkenyl, (C.sub.1-4)alkylsulphonyl, trifluoromethylsulphonyl, (C.sub.2-4)alkenylsulphonyl, (C.sub.1-4)alkoxycarbonyl, (C.sub.1-4)alkylcarbonyl, (C.sub.2-4)alkenyloxycarbonyl or (C.sub.2-4)alkenylcarbonyl; cyano; tetrazolyl; 2-oxo-oxazolidinyl optionally substituted by R.sup.10; 3-hydroxy-3-cyclobutene-1,2-dione-4-yl; 2,4-thiazolidinedione-5-yl; tetrazol-5-ylaminocarbonyl; 1,2,4-triazol-5-yl optionally substituted by R.sup.10; 5-oxo-1,2,4-oxadiazol-3-yl; halogen; (C.sub.1-4)alkylthio; trifluoromethyl; hydroxy optionally substituted by (C.sub.1-4)alkyl, (C.sub.2-4)alkenyl, (C.sub.1-4)alkoxycarbonyl, (C.sub.1-4)alkylcarbonyl, (C.sub.2-4)alkenyloxycarbonyl, (C.sub.2-4)alkenylcarbonyl; oxo; (C.sub.1-4)alkylsulphonyl; (C.sub.2-4)alkenylsulphonyl; or (C.sub.1-4)aminosulphonyl wherein the amino group is optionally substituted by (C.sub.1-4)alkyl or (C.sub.2-4)alkenyl; when R.sup.v and R.sup.w are a bond, R.sup.3 is in the 2- or 3-position and when R.sup.v and R.sup.w are not a bond, R.sup.3 is in the 1-, 2-, or 3-position and R.sup.3 is: hydrogen; carboxy; (C.sub.1-6)alkoxycarbonyl; aminocarbonyl wherein the amino group is optionally substituted by hydroxy, (C.sub.1-6)alkyl, hydroxy(C.sub.1-6)alkyl, aminocarbonyl(C.sub.1-6)alkyl, (C.sub.2-6)alkenyl, (C.sub.1-6)alkylsulphonyl, trifluoromethylsulphonyl, (C.sub.2-6)alkenylsulphonyl, (C.sub.1-6)alkoxycarbonyl, (C.sub.1-6)alkylcarbonyl, (C.sub.2-6)alkenyloxycarbonyl or (C.sub.2-6)alkenylcarbonyl and optionally further substituted by (C.sub.1-6)alkyl, hydroxy(C.sub.1-6)alkyl, aminocarbonyl(C.sub.1-6)alkyl or (C.sub.2-6)alkenyl; cyano; tetrazolyl; 2-oxo-oxazolidinyl optionally substituted by R.sup.10; 3-hydroxy-3-cyclobutene-1,2-dione-4-yl; 2,4-thiazolidinedione-5-yl; tetrazol-5-ylaminocarbonyl; 1,2,4-triazol-5-yl optionally substituted by R.sup.10; or 5-oxo-1,2,4-oxadiazol-3-yl; or (C.sub.1-4)alkyl or ethenyl optionally substituted with any of the groups listed above for R.sup.3 and/or 0 to 2 groups R.sup.12 independently selected from: halogen; (C.sub.1-6)alkylthio; trifluoromethyl; (C.sub.1-6)alkoxycarbonyl; (C.sub.1-6)alkylcarbonyl; (C.sub.2-6)alkenyloxycarbonyl; (C.sub.2-6)alkenylcarbonyl; hydroxy optionally substituted by (C.sub.1-6)alkyl, (C.sub.2-6)alkenyl, (C.sub.1-6)alkoxycarbonyl, (C.sub.1-6)alkylcarbonyl, (C.sub.2-6)alkenyloxycarbonyl, (C.sub.2-6)alkenylcarbonyl or aminocarbonyl wherein the amino group is optionally substituted by (C.sub.1-6)alkyl, (C.sub.2-6)alkenyl, (C.sub.1-6)alkylcarbonyl or (C.sub.2-6)alkenylcarbonyl; amino optionally mono- or disubstituted by (C.sub.1-6)alkoxycarbonyl, (C.sub.1-6)alkylcarbonyl, (C.sub.2-6)alkenyloxycarbonyl, (C.sub.2-6)alkenylcarbonyl, (C.sub.1-6)alkyl, (C.sub.2-6)alkenyl, (C.sub.1-6)alkylsulphonyl, (C.sub.2-6)alkenylsulphonyl or aminocarbonyl wherein the amino group is optionally substituted by (C.sub.1-6)alkyl or (C.sub.2-6)alkenyl; aminocarbonyl wherein the amino group is optionally substituted by (C.sub.1-6)alkyl, hydroxy(C.sub.1-6)alkyl, aminocarbonyl(C.sub.1-6)alkyl, (C.sub.2-6)alkenyl, (C.sub.1-6)alkoxycarbonyl, (C.sub.1-6)alkylcarbonyl, (C.sub.2-6)alkenyloxycarbonyl or (C.sub.2-6)alkenylcarbonyl and optionally further substituted by (C.sub.1-6)alkyl, hydroxy(C.sub.1-6)alkyl, aminocarbonyl(C.sub.1-6)alkyl or (C.sub.2-6)alkenyl; oxo; (C.sub.1-6)alkylsulphonyl; (C.sub.2-6)alkenylsulphonyl; or (C.sub.1-6)aminosulphonyl wherein the amino group is optionally substituted by (C.sub.1-6)alkyl or (C.sub.2-6)alkenyl; or hydroxy optionally substituted by (C.sub.1-6)alkyl, (C.sub.2-6)alkenyl, (C.sub.1-6)alkoxycarbonyl, (C.sub.1-6)alkylcarbonyl, (C.sub.2-6)alkenyloxycarbonyl, (C.sub.2-6)alkenylcarbonyl or aminocarbonyl wherein the amino group is optionally substituted by (C.sub.1-6)alkyl, (C.sub.2-6)alkenyl, (C.sub.1-6)alkylcarbonyl or (C.sub.2-6)alkenylcarbonyl; or amino optionally mono- or disubstituted by (C.sub.1-6)alkoxycarbonyl, (C.sub.1-6)alkylcarbonyl, (C.sub.2-6)alkenyloxycarbonyl, (C.sub.2-6)alkenylcarbonyl, (C.sub.1-6)alkyl, (C.sub.2-6)alkenyl, (C.sub.1-6)alkylsulphonyl, (C.sub.2-6)alkenylsulphonyl or aminocarbonyl wherein the amino group is optionally substituted by (C.sub.1-6)alkyl or (C.sub.2-6)alkenyl; in addition when R.sup.3 is disubstituted with a hydroxy or amino containing substituent and a carboxy containing substituent these may optionally together form a cyclic ester or amide linkage, respectively; n is 0 or 1 and AB is NR.sup.11CO, CONR.sup.11, CO--CR.sup.8R.sup.9, CR.sup.6R.sup.7-CO, O--CR.sup.8R.sup.9, CR.sup.6R.sup.7-O, NR.sup.11--CR.sup.8R.sup.9, CR.sup.6R.sup.7-NR.sup.11, NR.sup.11SO.sub.2, CR.sup.6R.sup.7--SO.sub.2 or CR.sup.6R.sup.7-CR.sup.8R.sup.9, provided that when R.sup.v and R.sup.w are a bond and n=0, B is not NR.sup.11, O or SO.sub.2, or n is 0 and AB is NH--CO--NH or NH--CO--O and R.sup.v/R.sup.w are not a bond; or n is 0 and AB is CR.sup.6R.sup.7SO.sub.2NR.sup.2, CR.sup.6R.sup.7CONR.sup.2 or CR.sup.6R.sup.7CH.sub.2NR.sup.2 and R.sup.v/R.sup.w are not a bond; provided that R.sup.6 and R.sup.7, and R.sup.8 and R.sup.9 are not both optionally substituted hydroxy or amino: and wherein: each of R.sup.6, R.sup.7, R.sup.8 and R.sup.9 is independently selected from: H; (C.sub.1-6)alkoxy; (C.sub.1-6)alkylthio; halo; trifluoromethyl; azido; (C.sub.1-6)alkyl; (C.sub.2-6)alkenyl; (C.sub.1-6)alkoxycarbonyl; (C.sub.1-6)alkylcarbonyl; (C.sub.2-6)alkenyloxycarbonyl; (C.sub.2-6)alkenylcarbonyl; hydroxy, amino or aminocarbonyl optionally substituted as for corresponding substituents in R.sup.3; (C.sub.1-6)alkylsulphonyl; (C.sub.2-6)alkenylsulphonyl; or (C.sub.1-6)aminosulphonyl wherein the amino group is optionally substituted by (C.sub.1-6)alkyl or (C.sub.2-6)alkenyl; or R.sup.6 and R.sup.8 together represent a bond and R.sup.7 and R.sup.9 are as above defined; R.sup.10 is selected from (C.sub.1-4)alkyl and (C.sub.2-4) alkenyl either of which may be optionally substituted by a group R.sup.12 as defined above; carboxy; aminocarbonyl wherein the amino group is optionally substituted by hydroxy, (C.sub.1-6)alkyl, (C.sub.2-6)alkenyl, (C.sub.1-6)alkylsulphonyl, trifluoromethylsulphonyl, (C.sub.2-6)alkenylsulphonyl, (C.sub.1-6)alkoxycarbonyl, (C.sub.1-6)alkylcarbonyl, (C.sub.2-6)alkenyloxycarbonyl or (C.sub.2-6)alkenylcarbonyl and optionally further substituted by (C.sub.1-6)alkyl or (C.sub.2-6)alkenyl; (C.sub.1-6)alkylsulphonyl; trifluoromethylsulphonyl; (C.sub.2-6)alkenylsulphonyl; (C.sub.1-6)alkoxycarbonyl; (C.sub.1-6)alkylcarbonyl; (C.sub.2-6)alkenyloxycarbonyl; and (C.sub.2-6)alkenylcarbonyl; and each R.sup.11 is independently H; trifluoromethyl; (C.sub.1-6)alkyl; (C.sub.1-6)alkoxycarbonyl; (C.sub.1-6)alkylcarbonyl; or aminocarbonyl wherein the amino group is optionally substituted by (C.sub.1-6)alkoxycarbonyl, (C.sub.1-6)alkylcarbonyl, (C.sub.2-6)alkenyloxycarbonyl, (C.sub.2-6)alkenyloxycarbonyl, (C.sub.1-6)alkyl or (C.sub.2-6)alkenyl and optionally further substituted by (C.sub.1-6)alkyl or (C.sub.2-6)alkenyl.

13. A compound of formula (VII): ##STR00141## wherein one of Z.sup.1, Z.sup.2, or Z.sup.3 is N, one of the remainder of Z.sup.1, Z.sup.2, Z.sup.3, Z.sup.4, and Z.sup.5 is CR.sup.1a and the remainder are CH; R.sup.v and R.sup.w are hydrogen; R.sup.v is R.sup.3; or R.sup.v and R.sup.w together are a bond; R.sup.1 and R.sup.1a are independently selected from hydrogen; hydroxy; (C.sub.1-6) alkoxy optionally substituted by (C.sub.1-6)alkoxy, amino, piperidyl, guanidino or amidino any of which is optionally N-substituted by one or two (C.sub.1-6)alkyl, (C.sub.1-6)alkoxycarbonyl, formyl, (C.sub.1-6)alkylcarbonyl, or (C.sub.1-6)alkylsulphonyl groups, CONH2, hydroxy, (C.sub.1-6)alkylthio, heterocyclylthio, heterocyclyloxy, arylthio, aryloxy, (C.sub.1-6)alkyloxycarbonylthio; formylthio; (C.sub.1-6)alkylcarbonylthio; (C.sub.1-6)alkyloxycarbonyloxy; formyloxy, (C.sub.1-6)alkylcarbonyloxy or (C.sub.1-6)alkylsulphonyloxy; (C.sub.1-6)alkoxy-substituted (C.sub.1-6)alkyl; halogen; (C.sub.1-6)alkyl; (C.sub.1-6)alkylthio; trifluromethyl; nitro; azido; (C.sub.1-6)alkoxycarbonyl; formyl; (C.sub.1-6)alkylcarbonyl; (C.sub.1-6)alkyloxycarbonyloxy; formyloxy; (C.sub.1-6)alkylcarbonyloxy; (C.sub.1-6)alkyloxycarbonylthio; formylthio; (C.sub.1-6)alkylcarbonylthio; (C.sub.1-6)alkylsulphonyl; (C.sub.1-6)alkylsulphoxide; arylsulphonyl; arylsulphoxide or an amino, piperidyl, guanidino or amidino group optionally N-substituted by one or two (C.sub.1-6)alkyl, (C.sub.1-6)alkoxycarbonyl, formyl, (C.sub.1-6)alkylcarbonyl or (C.sub.1-6)alkylsulphonyl groups, or when Z.sup.1 is CR.sup.1a, R.sup.1a may together represent (C.sub.1-2)alkylenedioxy; or when Z.sup.5 is CR.sup.1a, R.sup.1a may instead by cyano, hydroxymethyl or carboxy; R.sup.2 is hydrogen, or (C.sub.1-4)alkyl or (C.sub.2-4)alkenyl optionally substituted with 1 to 3 groups selected from: amino optionally substituted by one or two (C.sub.1-4)alkyl groups; carboxy; (C.sub.1-4)alkoxycarbonyl; (C.sub.1-4)alkylcarbonyl; (C.sub.2-4)alkenyloxycarbonyl; (C.sub.2-4)alkenylcarbonyl; aminocarbonyl wherein the amino group is optionally substituted by hydroxy, (C.sub.1-4)alkyl, hydroxy(C.sub.1-4)alkyl, aminocarbonyl(C.sub.1-4)alkyl, (C.sub.2-4)alkenyl, (C.sub.1-4)alkylsulphonyl, trifluoromethylsulphonyl, (C.sub.2-4)alkenylsulphonyl, (C.sub.1-4)alkoxycarbonyl, (C.sub.1-4)alkylcarbonyl, (C.sub.2-4)alkenyloxycarbonyl or (C.sub.2-4)alkenylcarbonyl; cyano; tetrazolyl; 2-oxo-oxazolidinyl optionally substituted by R.sup.10; 3-hydroxy-3-cyclobutene-1,2-dione-4-yl; 2,4-thiazolidinedione-5-yl; tetrazol-5-ylaminocarbonyl; 1,2,4-triazol-5-yl optionally substituted by R.sup.10; 5-oxo-.sup.1,2,4-oxadiazol-3-yl; halogen; (C.sub.1-4)alkylthio; trifluoromethyl; hydroxy optionally substituted by (C.sub.1-4)alkyl, (C.sub.2-4)alkenyl, (C.sub.1-4)alkoxycarbonyl; (C.sub.1-4)alkylcarbonyl; (C.sub.2-4)alkenyloxycarbonyl, (C.sub.2-4)alkenylcarbonyl; oxo; (C.sub.1-4)alkylsulphonyl; (C.sub.2-4)alkenylsulphonyl; or (C.sub.1-4)aminosulphonyl wherein the amino group is optionally substituted by (C.sub.1-4)alkyl or (C.sub.2-4)alkenyl; when R.sup.10 and R.sup.w are a bond, R.sup.3 is in the 2- or 3-position and when R.sup.v and R.sup.w are not a bond, R.sup.3 is in the 1-, 2-, 3-, and 4-position and R.sup.3 is; hydrogen; carboxy; (C.sub.1-6)alkoxycarbonyl; aminocarbonyl wherein the amino group is optionally substituted by hydroxy, (C.sub.1-6)alkyl, hydroxy(C.sub.1-4)alkyl, aminocarbonyl(C.sub.1-6)alkyl, (C.sub.2-6)alkenyl, (C.sub.1-6)alkylsulphonyl, trifluoromethylsulphonyl, (C.sub.2-6)alkenylsulphonyl, (C.sub.1-6)alkoxycarbonyl, (C.sub.1-6)alkylcarbonyl, (C.sub.2-6)alkenyloxycarbonyl or (C.sub.2-6)alkenylcarbonyl and optionally further substituted by (C.sub.1-6)alkyl, hydroxy(C.sub.1-6)alkyl, aminocarbonyl(C.sub.1-6)alkyl or (C.sub.2-6)alkenyl; cyano; tetrazolyl; 2-oxo-oxazolidinyl optionally substituted by R.sup.10; 3-hydroxy-3-cyclobutene-1,2-dione-4-yl; 2,4-thiazolidinedione-5-yl; tetrazol-5-ylaminocarbonyl; 1,2,4-triazol-5-yl optionally substituted by R.sup.10; or 5-oxo-1,2,4-oxadiazol-3-yl; or (C.sub.1-4)alkyl or ethenyl optionally substituted with any of the groups listed above for R.sup.3 and/or 0 to 2 groups R.sup.12 independently selected from: halogen; (C.sub.1-6)alkylthio; trifluoromethyl; (C.sub.1-6)alkoxycarbonyl; (C.sub.1-6)alkylcarbonyl; (C.sub.2-6)alkenyloxycarbonyl; (C.sub.2-6)alkenylcarbonyl; hydroxy optionally substituted by (C.sub.1-6 )alkyl, (C.sub.2-6)alkenyl, (C.sub.1-6)alkoxycarbonyl, (C.sub.1-6)alkylcarbonyl, (C.sub.2-6)alkenyloxycarbonyl, (C.sub.2-6)alkenylcarbonyl or aminocarbonyl wherein the amino group is optionally substituted by (C.sub.1-6)alkyl, (C.sub.2-6)alkenyl, (C.sub.1-6)alkylcarbonyl or (C.sub.2-6)alkenylcarbonyl; amino optionally mono- or disubstituted by (C.sub.1-6)alkoxycarbonyl, (C.sub.1-6)alkylcarbonyl, (C.sub.2-6)alkenyloxycarbonyl, (C.sub.2-6)alkenylcarbonyl, (C.sub.1-6)alkyl, (C.sub.2-6)alkenyl, (C.sub.1-6)alkylsulphonyl, (C.sub.2-6)alkenylsulphonyl or aminocarbonyl wherein the amino group is optionally substituted by (C.sub.1-6)alkyl or (C.sub.2-6)alkenyl; aminocarbonyl wherein the amino group is optionally substituted by (C.sub.1-6)alkyl, hydroxy (C.sub.1-6)alkyl, aminocarbonyl(C.sub.1-6)alkyl, (C.sub.2-6)alkenyl, (C.sub.1-6)alkoxycarbonyl, (C.sub.1-6)alkylcarbonyl, (C.sub.2-6)alkenyloxycarbonyl or (C.sub.2-6)alkenylcarbonyl and optionally further substituted by (C.sub.1-6)alkyl, hydroxy(C.sub.1-6)alkyl, aminocarbonyl(C.sub.1-6)alkyl or (C.sub.2-6)alkenyl; oxo; (C.sub.1-6)alkylsulphonyl; (C.sub.2-6)alkenylsulphonyl; or (C.sub.1-6)aminosulphonyl wherein the amino group is optionally substituted by (C.sub.1-6)alkyl or (C.sub.2-6)alkenyl; or hydroxy optionally substituted by (C.sub.1-6)alkyl, (C.sub.2-6)alkenyl, (C.sub.1-6)alkoxycarbonyl, (C.sub.1-6)alkylcarbonyl, (C.sub.2-6)alkenyloxycarbonyl, (C.sub.2-6)alkenylcarbonyl or aminocarbonyl wherein the amino group is optionally substituted by (C.sub.1-6)alkyl, (C.sub.2-6)alkenyl, (C.sub.1-6)alkylcarbonyl or (C.sub.2-6)alkenylcarbonyl; or amino optionally mono- or disubstituted by (C.sub.1-6)alkoxycarbonyl, (C.sub.2-6)alkylcarbonyl, (C.sub.2-6)alkenyloxycarbonyl, (C.sub.2-6)alkenylcarbonyl, (C.sub.1-6)alkyl, (C.sub.2-6)alkenyl, (C.sub.1-6)alkylsulphonyl, (C.sub.2-6)alkenylsulphonyl or aminocarbonyl wherein the amino group is optionally substituted by (C.sub.1-6)alkyl or (C.sub.2-6)alkenyl; in addition when R.sup.3 is disubstituted with a hydroxy or amino containing substituent and a carboxy containing substituent these may optionally together form a cyclic ester or amide linkage, respectively; provided that when R.sup.3 is in the 4-position it is not optionally substituted hydroxyl or amino; n is 0 or 1 and AB is NR.sup.11CO, CONR.sup.11, CO--CR.sup.8R.sup.9, CR.sup.6R.sup.7-CO, O--CR.sup.8R.sup.9, CR.sup.6R.sup.7-O, NR.sup.11--CR.sup.8R.sup.9, CR.sup.6R.sup.7- NR.sup.11, NR.sup.11SO.sub.2, CR.sup.6F.sup.7--SO.sub.2 or CR.sup.6R.sup.7-CR.sup.8R.sup.9, provided that when R.sup.v and R.sup.w are a bond and n=0, B is not NR.sup.11, O or SO.sub.2, or n is 0 and AB is NH--CO--NH or NH--CO--O and R.sup.v/R.sup.w are not a bond; or n is 0 and AB is CR.sup.6R.sup.7SO.sub.2NR.sup.2, CR.sup.6R.sup.7CONR.sup.2 or CR.sup.6R.sup.7CH.sub.2NR.sup.2 and R.sup.v/R.sup.w are not a bond; provided that R.sup.6 and R.sup.7, and R.sup.8 and R.sup.9 are not both optionally substituted hydroxy or amino; and wherein; each of R.sup.6, R.sup.7, R.sup.8 and R.sup.9 is independently selected from; H; (C.sub.1-6)alkoxy; (C.sub.1-6)alkylthio; halo; trifluoromethyl; azido; (C.sub.1-6)alkyl; (C.sub.2-6)alkenyl; (C.sub.1-6)alkoxycarbonyl; (C.sub.1-6)alkylcarbonyl; (C.sub.2-6)alkenyloxycarbonyl; (C.sub.2-6)alkenylcarbonyl; hydroxy, amino or aminocarbonyl optionally substituted as for corresponding substituents in R.sup.3; (C.sub.1-6)alkylsulphonyl; (C.sub.1-6)alkenylsulphonyl; or (C.sub.1-6)aminosulphonyl wherein the amino group is optionally substituted by (C.sub.1-6)alkyl or (C.sub.2-6)alkenyl; or R.sup.6 and R.sup.8 together represent a bond and R.sup.7 and R.sup.9 are as above defined; R.sup.10 is selected from (C.sub.1-4)alkyl and (C.sub.2-4)alkenyl either of which may be optionally substituted by a group R.sup.12 as defined above; carboxy; aminocarbonyl wherein the amino group is optionally substituted by hydroxy, (C.sub.1-6)alkyl, (C.sub.2-6)alkenyl, (C.sub.1-6)alkylsulphonyl, trifluoromethylsulphonyl, (C.sub.1-6)alkenylsulphonyl, (C.sub.1-6)alkoxycarbonyl, (C.sub.1-6)alkylcarbonyl, (C.sub.2-6)alkenyloxycarbonyl or (C.sub.2-6)alkenylcarbonyl and optionally further substituted by (C.sub.1-6)alkyl or (C.sub.2-6)alkenyl; (C.sub.1-6)alkylsulphonyl; trifluoromethylsulphonyl; (C.sub.2-6)alkenylsulphonyl; (C.sub.1-6)alkoxycarbonyl; (C.sub.1-6)alkylcarbonyl; (C.sub.2-6)alkenyloxycarbonyl; and (C.sub.2-6)alkenylcarbonyl; and each R.sup.11 is independently H; trifluoromethyl; (C.sub.1-6)alkyl; (C.sub.2-6)alkenyl; (C.sub.1-6)alkoxycarbonyl; (C.sub.1-6)alkylcarbonyl; or aminocarbonyl wherein the amino group is optionally substituted by (C.sub.1-6)alkoxycarbonyl; (C.sub.1-6)alkylcarbonyl, (C.sub.2-6)alkenyloxycarbonyl, (C.sub.2-6)alkenylcarbonyl, (C.sub.1-6)alkyl or (C.sub.2-6)alkenyl and optionally further substituted by (C.sub.1-6)alkyl or (C.sub.2-6)alkenyl.

14. The method of claim 10 wherein the mammal is human.
Description



This invention relates to novel compounds, compositions containing them and their use as antibacterials.

WO099/37635, WO00/21948, WO00/21952, WO00/43383, WO00/78748, WO01/07433, WO01/07432, WO02/08224, WO02/24684 and WO01/25227 disclose quinoline and naphthyridine derivatives having antibacterial activity.

This invention provides a compound of formula (I) or a pharmaceutically acceptable derivative thereof: ##STR00001## wherein: one of Z.sup.1, Z.sup.2, Z.sup.3, Z.sup.4 and Z.sup.5 is N, one is CR.sup.1a and the remainder are CH, or one of Z.sup.1, Z.sup.2, Z.sup.3, Z.sup.4 and Z.sup.5 is CR.sup.1a and the remainder are CH; R.sup.v and R.sup.w are hydrogen or R.sup.v and R.sup.w together are a bond; R.sup.1 and R.sup.1a are independently selected from hydrogen; hydroxy; (C.sub.1-6) alkoxy optionally substituted by (C.sub.1-6)alkoxy, amino, piperidyl, guanidino or amidino any of which is optionally N-substituted by one or two (C.sub.1-6)alkyl, acyl or (C.sub.1-6)alkylsulphonyl groups, CONH2, hydroxy, (C.sub.1-6)alkylthio, heterocyclylthio, heterocyclyloxy, arylthio, aryloxy, acylthio, acyloxy or (C.sub.1-6)alk


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