Orally administered peptides to ameliorate atherosclerosis Number:7,144,862 from the United States Patent and Trademark Office (PTO) owispatent This invention provides novel peptides that ameliorate one or more symptoms of atherosclerosis. In certain embodiments, the peptide comprises an amino acid sequence that ranges in length from about 10 up to about 30 amino acids, that comprises at least one class A amphipathic helix, that bears at least one protecting group, that protects a phospholipid against oxidation by an oxidizing agent; and that is not the D-18A peptide. The peptides are highly stable and readily administered via an oral route.<H atherosclerosis, administered, Orally, administ, 7144862.html, Patent, pto, 7144862

Title: Orally administered peptides to ameliorate atherosclerosis

Abstract: This invention provides novel peptides that ameliorate one or more symptoms of atherosclerosis. In certain embodiments, the peptide comprises an amino acid sequence that ranges in length from about 10 up to about 30 amino acids, that comprises at least one class A amphipathic helix, that bears at least one protecting group, that protects a phospholipid against oxidation by an oxidizing agent; and that is not the D-18A peptide. The peptides are highly stable and readily administered via an oral route.

Patent Number: 7,144,862 Issued on 12/05/2006 to Fogelman, et al.

Inventors: Fogelman; Alan M. (Beverly Hills, CA), Anantharamaiah; Gattadahalli M. (Birmingham, AL), Navab; Mohamad (Los Angles, CA)
Assignee: The Regents of the University of California (Oakland, CA)
The University of Alabama Research Foundation (Birmingham, AL)

Appl. No.: 10/187,215

Filed: June 28, 2002

Related U.S. Patent Documents


Application Number	Filing Date	Patent Number	Issue Date
09896841	Jun., 2001
09645454	Aug., 2000	6664230

Current U.S. Class: 514/13 ; 530/326

Current International Class: A61K 38/10 (20060101); C07K 7/08 (20060101)

Field of Search: 514/12,13,14,15,21 530/324,325,326,327,328,345

References Cited [Referenced By]

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